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PSIP1 protein, human

Known as: Lens Epithelium-Derived Growth Factor, PC4 and SFRS1 interacting protein 1, human, PSIP1 
PC4 and SFRS1-interacting protein isoform 1 (530 aa, ~60 kDa) is encoded by the human PSIP1 gene. This protein plays a role in transcriptional… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

Adaptor Proteins, Signal TransducingTRANSCRIPTION FACTOR
CUX1 wt AlleleCell NucleusCellular Stress ResponseGenes, Regulator

Papers overview

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Highly Cited
2016
Highly Cited
2016
A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin
Significance HIV-1 requires integration for efficient gene expression, and the local chromatin environment significantly… 
Highly Cited
2012
Highly Cited
2012
Anti-DFS70/LEDGF Antibodies Are More Prevalent in Healthy Individuals Compared to Patients with Systemic Autoimmune Rheumatic Diseases
Objective. Antinuclear antibodies (ANA) are a serological hallmark of systemic autoimmune rheumatic diseases (SARD) such as… 
Highly Cited
2010
Highly Cited
2010
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.
Correction of genetic diseases requires integration of the therapeutic gene copy into the genome of patient cells. Retroviruses… 
Highly Cited
2006
Highly Cited
2006
An Essential Role for LEDGF/p75 in HIV Integration
Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically… 
Highly Cited
2005
Highly Cited
2005
A role for LEDGF/p75 in targeting HIV DNA integration
HIV DNA integration is favored in active genes, but the underlying mechanism is unclear. Cellular lens epithelium-derived growth… 
Highly Cited
2005
Highly Cited
2005
The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding*
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF… 
Highly Cited
2004
Highly Cited
2004
Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 Integrase*
Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) protein was recently identified as a… 
Highly Cited
2004
Highly Cited
2004
Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 Integrase*
The transcriptional coactivator lens epithelium-derived growth factor (LEDGF)/p75 acts as a chromatin tethering factor for human… 
Highly Cited
2000
Highly Cited
2000
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.
BACKGROUND Sera of patients with atopic dermatitis (AD) were found to have autoantibodies that reacted with tissue culture cell… 
Highly Cited
1998
Highly Cited
1998
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation
In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from… 
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