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PSIP1 wt Allele

Known as: PAIP, LEDGF, PC4 and SFRS1 Interacting Protein 1 wt Allele 
Human PSIP1 wild-type allele is located in the vicinity of 9p22.2 and is approximately 47 kb in length. This allele, which encodes 2 alternatively… 
National Institutes of Health

Related topics

Related topics

8 relations
9p22.2Homo sapiensNFKB2 genePSIP1 protein, human

Broader (1)

PSIP1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras
The capacity to integrate transgenes into the host cell genome makes retroviral vectors an interesting tool for gene therapy… 
2014
2014
Penggunaan Alat Bantu Mengajar ke Atas Guru Pelatih Bagi Topik Kerja Kayu, Paip dan Logam
A teacher who wanted to improve the effectiveness of teaching and learning in the classroom should master the quality and… 
Review
2014
Review
2014
Animal model studies on viral infections
One of the major missions of animal virology is to understand how viruses replicate and cause asymptomatic/symptomatic conditions… 
2013
2013
Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors
We recently identified a series of indole derivatives as active inhibitors of IN-LEDGF/p75 interaction through structure-based… 
2012
2012
Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking
Integration of viral-DNA into host chromosome mediated by the viral protein HIV-1 integrase (IN) is an essential step in the HIV… 
Review
2011
Review
2011
Inhibition of the interaction between HIV-1 integrase and its cofactor LEDGF/p75: a promising approach in anti-retroviral therapy.
Although 25 compounds are currently licensed as anti-HIV drugs, the development of multidrug-resistant viruses, as well as their… 
Review
2009
Review
2009
The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights
Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best… 
Highly Cited
2007
Highly Cited
2007
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.
Highly Cited
2007
Highly Cited
2007
Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
ABSTRACT Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds human immunodeficiency virus… 
2007
2007
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.
LEDGF/p75 is known to enhance the integrase strand transfer activity in vitro, but the underlying mechanism is unclear. Using an… 
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