Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes

@article{Feng2004HumanBA,
  title={Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes},
  author={Hao Feng and Hua Xiang and Ying-Wei Mao and Juan Wang and Jin-ping Liu and X L Huang and Yan Liu and Shaojun Liu and Chen Luo and Xuan-Jie Zhang and Yun Liu and David Wan-Cheng Li},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={7310-7321}
}
The proto-oncogene, bcl-2, has various functions besides its role in protecting cells from apoptosis. One of the functions is to regulate expression of other genes. Previous studies have demonstrated that Bcl-2 regulates activities of several important transcription factors including NF-κB and p53, and also their downstream genes. In our recent studies, we reported that Bcl-2 substantially downregulates expression of the endogenous αB-crystallin gene through modulating the transcriptional… CONTINUE READING

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