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PRKDC protein, human

Known as: DNA-PKcs, DNA- PKcs protein, human, DNAPK protein, human 
DNA-dependent protein kinase catalytic subunit (4128 aa, ~469 kDa) is encoded by the human PRKDC gene. This protein is involved in both DNA damage… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ… Expand
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Highly Cited
2012
Highly Cited
2012
DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage… Expand
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Highly Cited
2008
Highly Cited
2008
Since p53 was cloned and subsequently characterized as a tumor suppressor more the 20 years ago, more than 40,000 publications… Expand
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Highly Cited
2008
Highly Cited
2008
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to the site of DNA damage to form… Expand
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Highly Cited
2007
Highly Cited
2007
The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is rapidly phosphorylated at the Thr-2609 cluster and Ser-2056… Expand
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Highly Cited
2006
Highly Cited
2006
Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) upon ionizing radiation (IR) is essential for… Expand
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Highly Cited
2002
Highly Cited
2002
Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B… Expand
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Highly Cited
2002
Highly Cited
2002
DNA-dependent protein kinase (DNA-PK), composed of Ku70, Ku80, and the catalytic subunit (DNA-PKcs), is involved in repairing… Expand
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Highly Cited
2000
Highly Cited
2000
The DNA-dependent protein kinase (DNA-PK), consisting of Ku and the DNA-PK catalytic subunit (DNA-PKcs), and the DNA ligase IV… Expand
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Review
2000
Review
2000
Ku is a heterodimeric protein composed of ∼70- and ∼80-kDa subunits (Ku70 and Ku80) originally identified as an autoantigen… Expand
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