PRKDC protein, human

Known as: DNA-PKcs, DNA- PKcs protein, human, DNAPK protein, human 
DNA-dependent protein kinase catalytic subunit (4128 aa, ~469 kDa) is encoded by the human PRKDC gene. This protein is involved in both DNA damage… (More)

Topic mentions per year

Topic mentions per year

1996-2018
051019962018

Papers overview

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2013
2013
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ… (More)
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2013
2013
When the integrity of the genome is threatened, cells activate a complex, kinase-based signaling network to arrest the cell cycle… (More)
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Highly Cited
2011
Highly Cited
2011
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature… (More)
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2011
2011
DNA-dependent protein kinase (DNA-PK) plays a pivotal role in the repair of DNA double-strand breaks (DSB) and is centrally… (More)
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Highly Cited
2009
Highly Cited
2009
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that are generated by ionizing radiation and various DNA-damaging… (More)
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Highly Cited
2008
Highly Cited
2008
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to the site of DNA damage to form… (More)
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2005
2005
Previous reports have suggested a connection between reduced levels of the catalytic subunit of DNA-dependent protein kinases… (More)
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Highly Cited
1998
Highly Cited
1998
In mammalian cells, double-strand break repair and V(D)J recombination require DNA-dependent protein kinase (DNA-PK), a serine… (More)
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1998
1998
A 30-kb genomic segment containing the promoter and first 9 exons of PRKDC, the gene encoding the catalytic subunit (DNA-PKcs) of… (More)
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1996
1996
The scid gene product has been identified as the 460-kDa catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs p460), a… (More)
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