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DNA-dependent protein kinase
Known as:
DNA Dependent Protein Serine Threonine Kinase
, DNA-Dependent Protein Serine-Threonine Kinase
, dna pk
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A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR…
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National Institutes of Health
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Related topics
Related topics
14 relations
ATM protein, human
In Blood
PRKDC gene
PRKDC wt Allele
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PRKDC protein, human
Prkdc protein, mouse
Serine/Threonine-Protein Kinase TAO1, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Mre11: roles in DNA repair beyond homologous recombination
S. Zha
,
C. Boboila
,
F. Alt
Nature Structural &Molecular Biology
2009
Corpus ID: 205522532
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now…
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Highly Cited
1999
Highly Cited
1999
Structure of DNA‐dependent protein kinase: implications for its regulation by DNA
K. Leuther
,
O. Hammarsten
,
R. Kornberg
,
G. Chu
The EMBO journal
1999
Corpus ID: 23451323
DNA double‐strand breaks are created by ionizing radiation or during V(D)J recombination, the process that generates…
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Highly Cited
1999
Highly Cited
1999
DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage*
S. Burma
,
A. Kurimasa
,
+7 authors
David J. Chen
The Journal of Biological Chemistry
1999
Corpus ID: 45421628
Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA damage and correlates with accumulation…
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Highly Cited
1998
Highly Cited
1998
Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex
N. Barlev
,
V. Poltoratsky
,
+4 authors
S. Berger
Molecular and Cellular Biology
1998
Corpus ID: 41633566
ABSTRACT GCN5, a putative transcriptional adapter in humans and yeast, possesses histone acetyltransferase (HAT) activity which…
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Highly Cited
1998
Highly Cited
1998
Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain Kinases*
S. Trigon
,
H. Serizawa
,
J. Conaway
,
R. Conaway
,
S. Jackson
,
M. Morange
The Journal of Biological Chemistry
1998
Corpus ID: 24343921
The C-terminal part of the largest subunit of eukaryotic RNA polymerase II is composed solely of the highly repeated consensus…
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Highly Cited
1997
Highly Cited
1997
Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase
W. Giffin
,
J. Kwast-Welfeld
,
+6 authors
R. Haché
The Journal of Biological Chemistry
1997
Corpus ID: 21981175
NRE1 is a DNA sequence element through which Ku antigen/DNA-dependent protein kinase (DNA-PK) catalytic subunit represses the…
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Highly Cited
1996
Highly Cited
1996
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
T. Blunt
,
D. Gell
,
+4 authors
P. Jeggo
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 7907137
DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku…
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1994
1994
Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans.
D. Jacoby
,
P. C. Wensink
The Journal of biological chemistry
1994
Corpus ID: 41286699
Highly Cited
1993
Highly Cited
1993
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
Andrew J. Bannister
,
T. Gottlieb
,
T. Kouzarides
,
S. Jackson
Nucleic acids research
1993
Corpus ID: 20209293
The DNA-dependent protein kinase (DNA-PK) phosphorylates a number of transcription factors. Here, we show that the DNA-PK…
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Highly Cited
1990
Highly Cited
1990
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
S. Jackson
,
Judy J. MacDonald
,
S. Lees-Miller
,
R. Tjian
Cell
1990
Corpus ID: 20050684
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