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DNA-dependent protein kinase

Known as: DNA Dependent Protein Serine Threonine Kinase, DNA-Dependent Protein Serine-Threonine Kinase, dna pk 
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR… Expand
National Institutes of Health

Related topics

Related topics

14 relations
ATM protein, humanIn BloodPRKDC genePRKDC wt Allele
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Narrower (3)

PRKDC protein, humanPrkdc protein, mouseSerine/Threonine-Protein Kinase TAO1, human

Papers overview

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Highly Cited
2009
Highly Cited
2009
Mre11: roles in DNA repair beyond homologous recombination
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now… Expand
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Highly Cited
2008
Highly Cited
2008
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding.
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates the nonhomologous end joining pathway for repair of… Expand
Highly Cited
1999
Highly Cited
1999
Structure of DNA‐dependent protein kinase: implications for its regulation by DNA
DNA double‐strand breaks are created by ionizing radiation or during V(D)J recombination, the process that generates… Expand
Highly Cited
1999
Highly Cited
1999
DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage*
Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA damage and correlates with accumulation… Expand
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Highly Cited
1998
Highly Cited
1998
Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex
ABSTRACT GCN5, a putative transcriptional adapter in humans and yeast, possesses histone acetyltransferase (HAT) activity which… Expand
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Highly Cited
1997
Highly Cited
1997
Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase
NRE1 is a DNA sequence element through which Ku antigen/DNA-dependent protein kinase (DNA-PK) catalytic subunit represses the… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku… Expand
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1994
1994
Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans.
Yolk protein factor 1 (YPF1) is a heterodimeric DNA-binding protein from Drosophila melanogaster. In this report, we describe… Expand
Highly Cited
1993
Highly Cited
1993
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
The DNA-dependent protein kinase (DNA-PK) phosphorylates a number of transcription factors. Here, we show that the DNA-PK… Expand
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Highly Cited
1990
Highly Cited
1990
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
Efficient transcription of SV40 early genes requires transcription factor Sp1. Here, we report that SV40 infection induces Sp1… Expand
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