FAQ

DNA-dependent protein kinase

Known as: DNA Dependent Protein Serine Threonine Kinase, DNA-Dependent Protein Serine-Threonine Kinase, dna pk 
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR… (More)

Topic mentions per year

Topic mentions per year

1989-2018
020406019892018

Related topics

Related topics

16 relations
ATM protein, humanDNA-dependent protein kinase activityIn BloodPRKDC gene
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Narrower (2)

PRKDC protein, humanSerine/Threonine-Protein Kinase TAO1, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
DNA-dependent protein kinase
physiological aspects
chemical synthesis
Protein-Serine-Threonine Kinases
ATM protein, human
standards characteristics

Papers overview

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Highly Cited
2005
Highly Cited
2005
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia and Rad3-related (ATR) and DNA-dependent protein kinase catalytic… (More)
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Highly Cited
2005
Highly Cited
2005
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase.
Ionizing radiation, but not stimulation with epidermal growth factor (EGF), triggers EGF receptor (EGFR) import into the nucleus… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
Full activation of protein kinase B (PKB)/Akt requires phosphorylation on Thr-308 and Ser-473 by 3-phosphoinositide-dependent… (More)
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Highly Cited
2002
Highly Cited
2002
Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination
Mutations in the Artemis protein in humans result in hypersensitivity to DNA double-strand break-inducing agents and absence of B… (More)
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Highly Cited
2002
Highly Cited
2002
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.
Nonhomologous end-joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks (DSBs) in mammalian cells. The… (More)
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Highly Cited
1999
Highly Cited
1999
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
UNLABELLED Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and… (More)
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Highly Cited
1999
Highly Cited
1999
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.
Caffeine exposure sensitizes tumor cells to ionizing radiation and other genotoxic agents. The radiosensitizing effects of… (More)
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Highly Cited
1997
Highly Cited
1997
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
DNA-damaging agents signal to p53 through as yet unidentified posttranscriptional mechanisms. Here we show that phosphorylation… (More)
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Highly Cited
1993
Highly Cited
1993
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.
The DNA-dependent protein kinase (DNA-PK) phosphorylates Sp1 and several other nuclear proteins. Here, we show that Sp1 and the… (More)
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Highly Cited
1990
Highly Cited
1990
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase.
Efficient transcription of SV40 early genes requires transcription factor Sp1. Here, we report that SV40 infection induces Sp1… (More)
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