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DNA-dependent protein kinase

Known as: DNA Dependent Protein Serine Threonine Kinase, DNA-Dependent Protein Serine-Threonine Kinase, dna pk 
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR… Expand
National Institutes of Health

Related topics

Related topics

14 relations
ATM protein, humanIn BloodPRKDC genePRKDC wt Allele
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Narrower (3)

PRKDC protein, humanPrkdc protein, mouseSerine/Threonine-Protein Kinase TAO1, human

Papers overview

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2012
2012
Role of the translationally controlled tumor protein in DNA damage sensing and repair
The translationally controlled tumor protein (TCTP) is essential for survival by mechanisms that as yet are incompletely defined… Expand
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Highly Cited
2009
Highly Cited
2009
Mre11: roles in DNA repair beyond homologous recombination
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now… Expand
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2008
2008
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding.
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates the nonhomologous end joining pathway for repair of… Expand
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1999
1999
Structure of DNA-dependent protein kinase: implications for its regulation by DNA.
DNA double-strand breaks are created by ionizing radiation or during V(D)J recombination, the process that generates… Expand
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1999
1999
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage.
Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA damage and correlates with accumulation… Expand
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1998
1998
Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex.
GCN5, a putative transcriptional adapter in humans and yeast, possesses histone acetyltransferase (HAT) activity which has been… Expand
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1997
1997
Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase
NRE1 is a DNA sequence element through which Ku antigen/DNA-dependent protein kinase (DNA-PK) catalytic subunit represses the… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku… Expand
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1994
1994
Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans.
Yolk protein factor 1 (YPF1) is a heterodimeric DNA-binding protein from Drosophila melanogaster. In this report, we describe… Expand
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Highly Cited
1990
Highly Cited
1990
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
Efficient transcription of SV40 early genes requires transcription factor Sp1. Here, we report that SV40 infection induces Sp1… Expand
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