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DNA-dependent protein kinase

Known as: DNA Dependent Protein Serine Threonine Kinase, DNA-Dependent Protein Serine-Threonine Kinase, dna pk 
A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR… 
National Institutes of Health

Related topics

Related topics

14 relations
ATM protein, humanIn BloodPRKDC genePRKDC wt Allele

Narrower (3)

PRKDC protein, humanPrkdc protein, mouseSerine/Threonine-Protein Kinase TAO1, human

Papers overview

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Highly Cited
2009
Highly Cited
2009
Mre11: roles in DNA repair beyond homologous recombination
The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now… 
Highly Cited
1999
Highly Cited
1999
Structure of DNA‐dependent protein kinase: implications for its regulation by DNA
DNA double‐strand breaks are created by ionizing radiation or during V(D)J recombination, the process that generates… 
Highly Cited
1999
Highly Cited
1999
DNA-dependent Protein Kinase-independent Activation of p53 in Response to DNA Damage*
Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA damage and correlates with accumulation… 
Highly Cited
1998
Highly Cited
1998
Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex
ABSTRACT GCN5, a putative transcriptional adapter in humans and yeast, possesses histone acetyltransferase (HAT) activity which… 
Highly Cited
1998
Highly Cited
1998
Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain Kinases*
The C-terminal part of the largest subunit of eukaryotic RNA polymerase II is composed solely of the highly repeated consensus… 
Highly Cited
1997
Highly Cited
1997
Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase
NRE1 is a DNA sequence element through which Ku antigen/DNA-dependent protein kinase (DNA-PK) catalytic subunit represses the… 
Highly Cited
1996
Highly Cited
1996
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku… 
1994
1994
Yolk protein factor 1 is a Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans.
Highly Cited
1993
Highly Cited
1993
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
The DNA-dependent protein kinase (DNA-PK) phosphorylates a number of transcription factors. Here, we show that the DNA-PK… 
Highly Cited
1990
Highly Cited
1990
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
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