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PRKDC gene

Known as: protein kinase, DNA-activated, catalytic polypeptide, DNA-PKcs, HYPERRADIOSENSITIVITY COMPLEMENTING 1, MOUSE, HOMOLOG OF 
This gene plays a role in cellular homeostasis by transcription modulation. The gene is also involved in V(D)J recombination.
National Institutes of Health

Related topics

Related topics

13 relations
DNA RepairDNA-dependent protein kinaseNon-Homologous DNA End-JoiningPRKD1 gene

Narrower (1)

PRKDC wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Next-generation sequencing in thymic epithelial tumors uncovered novel genomic aberration sites and strong correlation between TMB and MSH6 single nucleotide variations.
2017
2017
PRKDC: A new candidate for checkpoint blockade immunotherapy?
3022Background: Immunologic checkpoint blockade with antibodies that target CTLA-4 or PD-1/PD-L1 have demonstrated promise in a… 
2016
2016
IL-10 and PRKDC polymorphisms are associated with glioma patient survival
Interleukin-10 (IL-10) and DNA repair gene PRKDC mutations are implicated in the development of multiple human cancers, including… 
2009
2009
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
2002
2002
Evidence for the involvement of DNA-dependent protein kinase in the phenomena of low dose hyper-radiosensitivity and increased radioresistance
Purpose : To investigate the role of DNA-dependent protein kinase (DNA-PK) in the phenomena of low dose hyper-radiosensitivity… 
2002
2002
Detection of ATM Gene Mutation in Human Glioma Cell Line M059J by a Rapid Frameshift/Stop Codon Assay in Yeast
Abstract Tsuchida, R., Yamada, T., Takagi, M., Shimada, A., Ishioka, Katsuki, Y., C., Igarashi, T., Chessa, L., Delia, D… 
2002
2002
DNA-PK and ATM are Required for Radiation-Enhanced Integration
Abstract Nimura, Y., Ismail, S. M., Chen, D. J. and Stevens, C. W. DNA-PK and ATM are Required for Radiation-Enhanced Integration… 
Highly Cited
2000
Highly Cited
2000
Complementation of the Radiosensitive M059J Cell Line
Abstract Hoppe, B. S., Jensen, R. B. and Kirchgessner, C.U. Complementation of the Radiosensitive M059J Cell Line. M059J is a… 
2000
2000
cDNA Expression Array Analysis of DNA Repair Genes in Human Glioma Cells that Lack or Express DNA-PK1
Abstract Galloway, A. M. and Allalunis-Turner, J. cDNA Expression Array Analysis of DNA Repair Genes in Human Glioma Cells that… 
1995
1995
The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair.
The murine severe combined immune deficiency mutation (scid) is characterized by a lack of B- and T-lymphoid cells due to a… 
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