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PRKD1 gene

Known as: PROTEIN KINASE D, PKCM, Protein Kinase D1 Gene 
This gene plays a role in protein phosphorylation and second messenger signaling.
National Institutes of Health

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Related topics

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Cell Proliferation Regulatory ProcessPRKDC genePhosphorylationSerine/Threonine Phosphorylation

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PRKD1 wt Allele

Papers overview

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2018
2018
Novel Mutations in the PKD1 and PKD2 Genes of Chinese Patients with Autosomal Dominant Polycystic Kidney Disease
Background/Aims: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder with mutations… 
2012
2012
Protein Kinase D1 Maintains the Epithelial Phenotype by Inducing a DNA-Bound, Inactive SNAI1 Transcriptional Repressor Complex
Background Protein Kinase D1 is downregulated in its expression in invasive ductal carcinoma of the breast and in invasive breast… 
Highly Cited
2012
Highly Cited
2012
PRRT2 Mutations in Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions in a Taiwanese Cohort
Background Mutations in the PRRT2 gene have recently been identified in patients with familial paroxysmal kinesigenic dyskinesia… 
Review
2010
Review
2010
Role of protein kinase D signaling in pancreatic cancer.
Highly Cited
2009
Highly Cited
2009
Protein Kinase D1 Autophosphorylation via Distinct Mechanisms at Ser744/Ser748 and Ser916*
Protein kinase D1 (PKD1) is a physiologically important signaling enzyme that is activated via protein kinase C-dependent trans… 
2008
2008
Involvement of Protein Kinase D in Phosphorylation and Increase of DNA Binding of Activator Protein 2&agr; to Downregulate ATP-Binding Cassette Transporter A1
Background—Activator protein (AP) 2&agr; negatively regulates expression of ABCA1 gene through Ser-phosphorylation of AP2&agr… 
Highly Cited
2006
Highly Cited
2006
Requirement of Protein Kinase D Tyrosine Phosphorylation for VEGF-A165-induced Angiogenesis through Its Interaction and Regulation of Phospholipase Cγ Phosphorylation*
Vascular endothelial cell growth factor-A165 (VEGF-A165) is critical for angiogenesis. Although protein kinase C-mediated protein… 
Highly Cited
2004
Highly Cited
2004
Oxidative Stress Induces Protein Kinase C-mediated Activation Loop Phosphorylation and Nuclear Redistribution of Protein Kinase D*
Oxidative stress induced by cell treatments with H2O2 activates protein kinase D (PKD) via a protein kinase C (PKC)-dependent… 
Highly Cited
1994
Highly Cited
1994
Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.
1. The patch clamp technique, together with intracellular perfusion of the catalytic fragment of protein kinase C (PKCM), was… 
Highly Cited
1990
Highly Cited
1990
Map of 16 polymorphic loci on the short arm of chromosome 16 close to the polycystic kidney disease gene (PKD1).
To define the PKD1 locus further, the gene involved in the most frequent form of adult polycystic kidney disease, probes from 16… 
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