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PPIase activity

Known as: peptidylprolyl cis-trans isomerase activity, peptidylproline cis-trans-isomerase activity, peptidylprolyl isomerase activity 
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
National Institutes of Health

Related topics

Related topics

11 relations
CyclophilinsFKBP2 geneFKBP6 geneImmunophilins

Narrower (2)

FK506-sensitive peptidyl-prolyl cis-trans isomerase activityjuglone-sensitive peptidyl-prolyl cis-trans isomerase activity

Broader (1)

protein peptidyl-prolyl isomerization

Papers overview

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Highly Cited
2013
Highly Cited
2013
The Cyclophilin CYP20-2 Modulates the Conformation of BRASSINAZOLE-RESISTANT1, Which Binds the Promoter of FLOWERING LOCUS D to Regulate Flowering in Arabidopsis[W][OPEN]
This work reports that the bHLH transcriptional factor BZR1 binds to the promoter of FLD, a putative histone demethylase gene… 
Highly Cited
2012
Highly Cited
2012
shutdown is a component of the Drosophila piRNA biogenesis machinery.
In animals, the piRNA pathway preserves the integrity of gametic genomes, guarding them against the activity of mobile genetic… 
Highly Cited
2010
Highly Cited
2010
Proteomics of life at low temperatures: trigger factor is the primary chaperone in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
The proteomes expressed at 4°C and 18°C by the psychrophilic Antarctic bacterium Pseudoalteromonas haloplanktis have been… 
Highly Cited
2006
Highly Cited
2006
The aggregation of alpha‐synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy
Aggregation of ±‐synuclein (±‐SYN) plays a key role in Parkinson's disease (PD). We have used fluorescence correlation… 
Highly Cited
1998
Highly Cited
1998
Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner
Abstract Mast cells play an important role in the pathological development of many inflammatory and allergic diseases and… 
Highly Cited
1994
Highly Cited
1994
Light-regulated, tissue-specific immunophilins in a higher plant.
In addition to their application in organ transplantation, immunosuppressive drugs are valuable tools for studying signal… 
Highly Cited
1992
Highly Cited
1992
A rapamycin-selective 25-kDa immunophilin.
FKBP25, a previously uncharacterized 25-kDa FK506- and rapamycin-binding protein, was purified to homogeneity from calf thymus… 
Highly Cited
1992
Highly Cited
1992
Isolation and characterization of a 40-kDa cyclophilin-related protein.
Highly Cited
1990
Highly Cited
1990
Probing immunosuppressant action with a nonnatural immunophilin ligand
The immunosuppressants FK506 and rapamycin bind to the same immunophilin, FK506 binding protein (FKBP), and inhibit distinct… 
Highly Cited
1990
Highly Cited
1990
The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.
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