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PPIase activity

Known as: peptidylprolyl cis-trans isomerase activity, peptidylproline cis-trans-isomerase activity, peptidylprolyl isomerase activity 
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
National Institutes of Health

Related topics

Related topics

11 relations
CyclophilinsFKBP2 geneFKBP6 geneImmunophilins

Narrower (2)

FK506-sensitive peptidyl-prolyl cis-trans isomerase activityjuglone-sensitive peptidyl-prolyl cis-trans isomerase activity

Broader (1)

protein peptidyl-prolyl isomerization

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Organization of the human FK 506-binding immunophilin FKBP 52 protein gene ( FKBP 4 )
FKBP52 is a widely expressed FK506-binding immunophilin that possesses peptidylprolyl isomerase activity and a tetratricopeptide… 
Review
1999
Review
1999
Neurophilins and the nervous system
Immunosuppressive drugs are being used increasingly to suppress rejection of organ transplants and to treat autoimmune disorders… 
1996
1996
Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.
Proliferation of the BJAB B-lymphoblastoid cell line was rapidly and almost completely suppressed by picomolar concentrations of… 
Review
1995
Review
1995
Receptor (Immunophilin‐Bhiding) Assay for Immunosuppressive Drugs
Summary The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP12) have been well characterized… 
Review
1995
Review
1995
Some new aspects of molecular mechanisms of cyclosporin A effect on immune response
A few protein targets were found to display a specific high‐affinity interaction with the immunosuppressant cyclosporin A (CsA… 
1994
1994
Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.
We isolated a novel gene encoding a protein highly homologous to human FK506-binding protein 12kDa (hFKBP-12) from a human fetal… 
1994
1994
Identification of a 14 kDa FK-506/rapamycin binding immunophilin from calf thymus.
Highly Cited
1992
Highly Cited
1992
A rapamycin-selective 25-kDa immunophilin.
FKBP25, a previously uncharacterized 25-kDa FK506- and rapamycin-binding protein, was purified to homogeneity from calf thymus… 
1992
1992
Neisseria meningitidis encodes an FK506-inhibitable rotamase.
Eukaryotic peptidyl-prolyl cis-trans isomerases (rotamases) fall into two classes, the cyclophilins inhibited by cyclosporin A… 
1991
1991
Structure‐function relationship of immunosuppressive drugs: A cautionary tale
The immunosuppressants FK506 and rapamycin bind to the same immunophilin, FK506 binding protein (FKBP), and inhibit distinct… 
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