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PPIase activity

Known as: peptidylprolyl cis-trans isomerase activity, peptidylproline cis-trans-isomerase activity, peptidylprolyl isomerase activity 
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). [EC:5.2.1.8]
National Institutes of Health

Related topics

Related topics

11 relations
CyclophilinsFKBP2 geneFKBP6 geneImmunophilins

Narrower (2)

FK506-sensitive peptidyl-prolyl cis-trans isomerase activityjuglone-sensitive peptidyl-prolyl cis-trans isomerase activity

Broader (1)

protein peptidyl-prolyl isomerization

Papers overview

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2004
2004
Transgenic mice overexpressing cyclophilin A are resistant to cyclosporin A-induced nephrotoxicity via peptidyl-prolyl cis-trans isomerase activity.
2003
2003
Organization of the human FK506-binding immunophilin FKBP52 protein gene (FKBP4).
2002
2002
The chaperone activity of protein disulfide isomerase is affected by cyclophilin B and cyclosporin A in vitro.
To elucidate the function of protein disulfide isomerase (PDI), we screened for PDI-binding proteins in a bovine liver extract… 
1997
1997
Functional Analysis of the Yeast 40 kDa Cyclophilin Cyp40 and Its Role for Viability and Steroid Receptor Regulation
We have identified and characterized a homolog of the 40 kDa cyclophilins in the budding yeast Saccharomyces cerevisiae. At the… 
1996
1996
Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.
Proliferation of the BJAB B-lymphoblastoid cell line was rapidly and almost completely suppressed by picomolar concentrations of… 
1994
1994
Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts.
We isolated a novel gene encoding a protein highly homologous to human FK506-binding protein 12kDa (hFKBP-12) from a human fetal… 
1994
1994
Identification of a 14 kDa FK-506/rapamycin binding immunophilin from calf thymus.
Highly Cited
1992
Highly Cited
1992
A rapamycin-selective 25-kDa immunophilin.
FKBP25, a previously uncharacterized 25-kDa FK506- and rapamycin-binding protein, was purified to homogeneity from calf thymus… 
1992
1992
Neisseria meningitidis encodes an FK506-inhibitable rotamase.
Eukaryotic peptidyl-prolyl cis-trans isomerases (rotamases) fall into two classes, the cyclophilins inhibited by cyclosporin A… 
1992
1992
FK-506-binding proteins from streptomycetes producing immunosuppressive macrolactones of the FK-506 type
FK-506-binding proteins (FKBPs), which in T cells are supposed to mediate the immunosuppressive effects of the compounds FK-506… 
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