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Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth
TLDR
This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth. Expand
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
TLDR
It is found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated, which may play a key role in mammalian oxygen sensing. Expand
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation*
TLDR
Findings strongly indicate that insulin-stimulated phosphorylation of AS160 is required for GLUT4 translocation and that this phosphorylated signals translocation through inactivation of the Rab GAP function. Expand
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
TLDR
Since INGs, HBO1, and MOZ/MORF contribute to oncogenic transformation, the multisubunit assemblies characterized here underscore the critical role of epigenetic regulation in cancer development. Expand
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
TLDR
The biochemical analysis of FACT is provided, providing evidence that Spt16/Cdc68 is involved in transcript elongation in vivo, and FACT specifically interacts with nucleosomes and histone H2A/H2B dimers, indicating that it may work by promoting nucleosome disassembly upon transcription. Expand
BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
TLDR
A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function. Expand
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
TLDR
This work reports the isolation of a novel SMRT-containing complex from HeLa cells that contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness and contains HDAC3, a histone deacetylase not previously thought to interact with SMRT. Expand
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
TLDR
Lactacystin appears to modify covalently the highly conserved amino-terminal threonine of the mammalian proteasome subunit X (also called MB1), a close homolog of the LMP7 proteasom subunit encoded by the major histocompatibility complex and may have a catalytic role. Expand
Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
TLDR
A previously unknown posttranslational modification of the DNA-binding domain of p53 is described, acetylation of lysine 120 (K120), which occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases hMOF and TIP60. Expand
Ordered Phosphorylation Governs Oscillation of a Three-Protein Circadian Clock
TLDR
A mathematical model constrained by experimental data quantitatively reproduces the circadian period and the distinctive dynamics of the four phosphoforms shown in an ordered pattern arising from the intrinsic autokinase and autophosphatase rates of KaiC and their modulation by KaiA. Expand
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