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Cyclophilins

Known as: Cyclophilin, Cyclophilins [Chemical/Ingredient], Cyclosporin-Binding Proteins 
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
National Institutes of Health

Related topics

Related topics

18 relations
In BloodPPIase activityProcess of secretionantagonists & inhibitors

Narrower (9)

PPID protein, humanPPIG protein, humanPeptidylprolyl IsomeraseSQN protein, Arabidopsis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Import and processing of heart mitochondrial cyclophilin D.
Cyclophilins are a family of cyclosporin-A-binding proteins which catalyse rotation about prolyl peptide bonds. A mitochondrial… 
Highly Cited
1997
Highly Cited
1997
Peptidyl prolyl cis-trans isomerase activity of cyclophilin A in functional homo-oligomeric receptor expression.
The functional expression of homo-oligomeric alpha7 neuronal nicotinic and type 3 serotonin receptors is dependent on the… 
Highly Cited
1996
Highly Cited
1996
Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
The structures of cyclophilin A complexed with dipeptides of Ser-Pro, His-Pro, and Gly-Pro have been determined and refined at… 
Highly Cited
1994
Highly Cited
1994
pCyP B: a chloroplast-localized, heat shock-responsive cyclophilin from fava bean.
When the immunosuppressants cyclosporin A (CsA) and FK506 bind to their intracellular receptors (immunophillins), they form… 
1993
1993
Kinetics of folding and association of differently glycosylated variants of invertase from saccharomyces cerevisiae
A core‐glycosylated form of the dimeric enzyme invertase has been isolated from secretion mutants of Saccharomyces cerevisiae… 
1992
1992
The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction.
1992
1992
Solution structure of cyclosporin A and a nonimmunosuppressive analog bound to fully deuterated cyclophilin.
A simple strategy involving 1H nuclear magnetic resonance (NMR) spectroscopy and complete protein deuteration was used to… 
1992
1992
Identification of actin and HSP 70 as cyclosporin A binding proteins by photoaffinity labeling and fluorescence displacement assays.
Highly Cited
1991
Highly Cited
1991
Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
The human T-cell protein cyclophilin shows high affinity for and is the proposed target of the major immunosuppressant drug… 
Highly Cited
1991
Highly Cited
1991
An endoplasmic reticulum-specific cyclophilin
Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive… 
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