Cyclophilins

Known as: Cyclophilin, Cyclophilins [Chemical/Ingredient], Cyclosporin-Binding Proteins 
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
National Institutes of Health

Related topics

Related topics

18 relations
In BloodPPIase activityProcess of secretionantagonists & inhibitors
(More)

Narrower (9)

PPID protein, humanPPIG protein, humanPeptidylprolyl IsomeraseSQN protein, Arabidopsis
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Target Cell Cyclophilins Facilitate Human Papillomavirus Type 16 Infection
Following attachment to primary receptor heparan sulfate proteoglycans (HSPG), human papillomavirus type 16 (HPV16) particles… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2005
Review
2005
The cyclophilins
Cyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Extracellular cyclophilins contribute to the regulation of inflammatory responses.
The main regulators of leukocyte trafficking during inflammatory responses are chemokines. However, another class of recently… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins.
BACKGROUND & AIMS Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.
The cyclophilins and FK506 binding proteins (FKBPs) bind to cyclosporin A, FK506, and rapamycin and mediate their… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid
The HIV-1 capsid protein forms the conical core structure at the center of the mature virion. Capsid also binds the human… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Functional association of cyclophilin A with HIV-1 virions
CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl–prolylcis–trans isomerase… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
The enzyme peptidyl-prolyl cis-trans isomerase (PPIase) was recently discovered in mammalian tissues and purified from porcine… (More)
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Cyclophilin: a specific cytosolic binding protein for cyclosporin A.
Cyclophilin, a specific cytosolic binding protein responsible for the concentration of the immunosuppressant cyclosporin A by… (More)
Is this relevant?