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Cyclophilins
Known as:
Cyclophilin
, Cyclophilins [Chemical/Ingredient]
, Cyclosporin-Binding Proteins
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A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
National Institutes of Health
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Related topics
Related topics
18 relations
In Blood
PPIase activity
Process of secretion
antagonists & inhibitors
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Narrower (9)
PPID protein, human
PPIG protein, human
Peptidylprolyl Isomerase
SQN protein, Arabidopsis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Susanne Pfefferle
,
Julia Schöpf
,
+25 authors
A. von Brunn
PLoS pathogens
2011
Corpus ID: 10209959
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological…
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Review
2005
Review
2005
The cyclophilins
P. Wang
,
J. Heitman
Genome Biology
2005
Corpus ID: 15607064
SummaryCyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans…
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Highly Cited
1996
Highly Cited
1996
Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid
T. R. Gamble
,
F. Vajdos
,
+4 authors
C. P. Hill
Cell
1996
Corpus ID: 6428295
The HIV-1 capsid protein forms the conical core structure at the center of the mature virion. Capsid also binds the human…
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Highly Cited
1994
Highly Cited
1994
Functional association of cyclophilin A with HIV-1 virions
M. Thali
,
A. Bukovsky
,
+4 authors
H. Göttlinger
Nature
1994
Corpus ID: 4371206
CYCLOPHILINS are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidylprolylcistrans isomerase…
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Highly Cited
1992
Highly Cited
1992
Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages.
B. Sherry
,
N. Yarlett
,
A. Strupp
,
A. Cerami
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 23501121
We have isolated an 18-kDa peptide (designated sp18, for 18-kDa secreted protein) from the conditioned medium of…
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Highly Cited
1991
Highly Cited
1991
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
J. Liu
,
Jesse D. Farmer
,
Willam S. Lane
,
J. Friedman
,
S. Schreiber
Cell
1991
Corpus ID: 22094672
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their…
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Highly Cited
1989
Highly Cited
1989
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins
G. Fischer
,
B. Wittmann-Liebold
,
K. Lang
,
T. Kiefhaber
,
F. Schmid
Nature
1989
Corpus ID: 10969060
The enzyme peptidyl-prolyl cis-trans isomerase (PPIase) was recently discovered in mammalian tissues and purified from porcine…
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Highly Cited
1989
Highly Cited
1989
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
N. Takahashi
,
T. Hayano
,
M. Suzuki
Nature
1989
Corpus ID: 4275952
Peptidyl-prolyl cis-trans isomerase (PPIase) catalyses the cis-trans isomerization of proline imidic peptide bonds in…
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Highly Cited
1989
Highly Cited
1989
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
J. Siekierka
,
S. H. Hung
,
M. Poe
,
C. Lin
,
N. Sigal
Nature
1989
Corpus ID: 4363530
CYCLOSPORIN A and the newly discovered immunosuppressant, FK-506, are potent inhibitors of T cell activation1. In addition to…
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Highly Cited
1984
Highly Cited
1984
Cyclophilin: a specific cytosolic binding protein for cyclosporin A.
R. Handschumacher
,
M. Harding
,
J. Rice
,
R. J. Drugge
,
D. Speicher
Science
1984
Corpus ID: 43338649
Cyclophilin, a specific cytosolic binding protein responsible for the concentration of the immunosuppressant cyclosporin A by…
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