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Cyclophilins

Known as: Cyclophilin, Cyclophilins [Chemical/Ingredient], Cyclosporin-Binding Proteins 
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
National Institutes of Health

Related topics

Related topics

18 relations
In BloodPPIase activityProcess of secretionantagonists & inhibitors

Narrower (9)

PPID protein, humanPPIG protein, humanPeptidylprolyl IsomeraseSQN protein, Arabidopsis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Interactions of Arabidopsis RS Domain Containing Cyclophilins with SR Proteins and U1 and U11 Small Nuclear Ribonucleoprotein-specific Proteins Suggest Their Involvement in Pre-mRNA Splicing*
Ser/Arg (SR)-rich proteins are important splicing factors in both general and alternative splicing. By binding to specific… 
Highly Cited
1996
Highly Cited
1996
Identification of two CyP‐40‐like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth
We report the analysis of two Saccharomyces cerevisiae cyclophilins, Cpr6 and Cpr7, identified by their ability to interact in… 
Highly Cited
1996
Highly Cited
1996
The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811
Human immunodeficiency virus type 1 (HIV-1) specifically incorporates the host cell peptidyl-prolyl isomerase cyclophilin A into… 
Highly Cited
1994
Highly Cited
1994
pCyP B: a chloroplast-localized, heat shock-responsive cyclophilin from fava bean.
When the immunosuppressants cyclosporin A (CsA) and FK506 bind to their intracellular receptors (immunophillins), they form… 
1994
1994
Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin.
1993
1993
Kinetics of folding and association of differently glycosylated variants of invertase from saccharomyces cerevisiae
A core‐glycosylated form of the dimeric enzyme invertase has been isolated from secretion mutants of Saccharomyces cerevisiae… 
1992
1992
The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction.
Highly Cited
1992
Highly Cited
1992
Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin
The cyclic undecapeptide cyclosporin A (CsA) is a slow-binding inhibitor of the peptidylprolyl cis-trans isomerase (PPIase… 
Highly Cited
1991
Highly Cited
1991
Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
The human T-cell protein cyclophilin shows high affinity for and is the proposed target of the major immunosuppressant drug… 
Highly Cited
1991
Highly Cited
1991
An endoplasmic reticulum-specific cyclophilin
Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive… 
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