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Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
The results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors.
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.
Examination of expression profiles of 20 primary HCCs and their corresponding noncancerous tissues by means of cDNA microarrays identified a number of genes associated with malignant histological type or invasive phenotype that will make it possible to define the nature of individual tumors.
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
Since an 8-base pair target site duplication was observed, retrotranscriptional insertion of an active LINE-1 sequence is suspected as the cause of this insertion event.
Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction
A typographical error in the third sentence of the abstract resulted in the P value for the association being incorrectly reported as P = 0.00000033, when the correct value is 0.0000033.
Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers.
Evidence is reported that the claudin-1 (CLDNI) gene is one of the genes regulated by beta-catenin, and that increased expression of claudIn-1 may have some role in colorectal tumorigenesis.
Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.
Exogenously expressed Tob is able to suppress growth of NIH3T3 cells, but the growth suppression is hampered by the presence of kinase-active p185erbB2, suggesting that other receptor-type protein-tyrosine kinases are also involved in the Tob-mediated regulation of cell growth.
Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)
The study suggests that NPPS plays an important role in the etiology of human OPLL, a common form of human myelopathy with a prevalence of as much as 4% in a variety of ethnic groups.
Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia.
The extensive list of genes identified in these experiments provides a large body of potentially valuable information of colorectal carcinogenesis and represents a source of novel targets for cancer therapy.