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Immunophilins

Known as: Immunophilins [Chemical/Ingredient] 
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (1)

FPR3 protein, S cerevisiae
In BloodNeurophilinsPPIase activityProcess of secretion

Broader (1)

Peptidylprolyl Isomerase

Papers overview

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Highly Cited
2004
Highly Cited
2004
Hsp90-binding Immunophilins Link p53 to Dynein During p53 Transport to the Nucleus*
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein… 
Review
2000
Review
2000
Immunophilins: Switched on protein binding domains?
  • M. Ivery
  • Medicinal research reviews (Print)
  • 2000
  • Corpus ID: 28669003
Peptidylprolyl isomerases (PPIases) are a group of cytosolic enzymes first characterized by their ability to catalyze the cis… 
Highly Cited
1996
Highly Cited
1996
A Model of Protein Targeting Mediated by Immunophilins and Other Proteins That Bind to hsp90 via Tetratricopeptide Repeat Domains*
We have shown recently that the immunophilins CyP-40 and FKBP52/hsp56 bind to a common site on hsp90 and that they exist in… 
Highly Cited
1995
Highly Cited
1995
The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed…
We have recently shown that hsp56, the FK506-binding immunophilin component of both the heat shock protein (hsp90•hsp70•hsp56… 
Highly Cited
1994
Highly Cited
1994
Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
THE immunosuppressive action of the drug FK506 involves inhibition of calcineurin in T-lymphocytes by a complex of FK506 and an… 
Review
1994
Review
1994
Immunophilins in protein folding and immunosuppression 1
Lymphocyte activation requires the transmission of signals from molecules at the plasma membrane to nuclear signals that regulate… 
Highly Cited
1994
Highly Cited
1994
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
The peptidyl‐prolyl isomerases FKBP12 and cyclophilin A (immunophilins) form complexes with the immunosuppressants FK506 and… 
Highly Cited
1993
Highly Cited
1993
The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59).
Highly Cited
1992
Highly Cited
1992
High brain densities of the immunophilin FKBP colocalized with calcineurin
THE immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the… 
Highly Cited
1992
Highly Cited
1992
Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.
Immunophilins, a family of proteins that exhibit rotamase (peptidyl-prolyl cis-trans isomerase) activity in vitro, are expressed… 
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