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Immunophilins

Known as: Immunophilins [Chemical/Ingredient] 
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cyclophilin A modulates susceptibility to abdominal aortic aneurysms in mice; mice that are deficient in this molecule are… Expand
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Highly Cited
2008
Highly Cited
2008
The immunophilin-like FKBP42 TWISTED DWARF1 (TWD1) has been shown to control plant development via the positive modulation of… Expand
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Review
2003
Review
2003
  • Andrzej Galat
  • Current topics in medicinal chemistry
  • 2003
  • Corpus ID: 11215031
Information recovered from genome sequencing projects, multiple sequence alignments, structural analyses of PPIase and published… Expand
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Highly Cited
2002
Highly Cited
2002
We have identified a new first step in the hormonal activation of the glucocorticoid receptor (GR). Rather than causing immediate… Expand
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Highly Cited
2000
Highly Cited
2000
MYC affects normal and neoplastic cell proliferation by altering gene expression, but the precise pathways remain unclear. We… Expand
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Review
1998
Review
1998
Successful expression of polypeptide gene products requires transcription machinery to generate messenger ribonucleic acids and… Expand
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Review
1996
Review
1996
Immunophilins are members of a highly conserved family of proteins all of which are cis-trans peptidyl-prolyl isomerases. The… Expand
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Highly Cited
1994
Highly Cited
1994
THE immunosuppressive action of the drug FK506 involves inhibition of calcineurin in T-lymphocytes by a complex of FK506 and an… Expand
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Highly Cited
1992
Highly Cited
1992
Calcineurin, a Ca2+, calmodulin-dependent protein phosphatase, was recently found to bind with high affinity to two different… Expand
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Review
1991
Review
1991
Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation… Expand
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