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PARP1 protein, human

Known as: ADPRT 1, Poly(ADP Ribose) Polymerase, NAD(+) ADP-Ribosyltransferase 1 
Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the… 
National Institutes of Health

Related topics

Related topics

32 relations
AIF PathwayAZD2461BRCT DomainBase Excision Repair

Broader (2)

Poly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerases

Papers overview

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2014
2014
Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kappaB-dependent signaling.
Poly(ADP-ribose) polymerase-1 (PARP-1) and its cleavage products regulate cell viability and NF-kappaB activity when expressed in… 
2011
2011
Phase I trial of veliparib, (ABT-888), a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with doxorubicin and cyclophosphamide in breast cancer and other solid tumors.
3041 Background: Veliparib is a potent, oral inhibitor of PARP-1 and PARP-2. We previously reported phase I results of veliparib… 
Review
2004
Review
2004
Poly(ADP-ribosyl)ation: a posttranslational proteinmodification linked with genome protection andmammalian longevity
Poly(ADP-ribosyl)ation is a posttranslationalmodification of nuclear proteins catalysed by the113-kDa enzyme poly(ADP-ribose… 
1996
1996
Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei
The polycistronic procylcin PARP (for procyclic acidic repetitive protein) A transcription unit of Trypanosoma brucei was… 
Review
1988
Review
1988
Modulation of chromatin structure by poly(ADP-ribosyl)ation.
Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity is totally dependent on the… 
Highly Cited
1987
Highly Cited
1987
Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA amplification in a Simian virus 40-transformed Chinese hamster cell line by 3-aminobenzamide.
A Simian virus 40-transformed Chinese hamster cell line (CO 60) amplifies integrated viral DNA sequences as a response to… 
Highly Cited
1984
Highly Cited
1984
Differential processing of ultraviolet or ionizing radiation-induced DNA-protein cross-links in Chinese hamster cells.
The yield and repairability of DNA-protein cross-links have been compared after gamma- or U.V.-irradiation of Chinese hamster V79… 
1982
1982
Poly(ADP-ribose) synthetase. The DNA binding domain and the automodification domain.
Poly(ADP-ribose) synthetase is known to require double-stranded DNA for activity and to be susceptible to automodification with… 
1980
1980
Initiation of poly(ADP-ribosyl) histone synthesis by poly(ADP-ribose) synthetase.
Initiation of poly(ADP-ribosyl) histone synthesis was achieved in vitro using an apparently homogeneous preparation of poly(ADP… 
1975
1975
Proceedings: Experimental manipulation of the specific activity of poly(ADP-ribose) polymerase.