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PARP1 protein, human

Known as: ADPRT 1, Poly(ADP Ribose) Polymerase, NAD(+) ADP-Ribosyltransferase 1 
Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the… 
National Institutes of Health

Related topics

Related topics

32 relations
AIF PathwayAZD2461BRCT DomainBase Excision Repair

Broader (2)

Poly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerases

Papers overview

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Highly Cited
2004
Highly Cited
2004
Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1*
Werner's syndrome (WS) is an inherited disease characterized by genomic instability and premature aging. The WS gene encodes a… 
Review
2002
Review
2002
Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?
Highly Cited
2001
Highly Cited
2001
Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.
The mammalian alpha-class glutathione S-transferase (GST) isozymes mGSTA4-4, rGSTA4-4, and hGSTA4-4 are known to utilize 4… 
Highly Cited
1999
Highly Cited
1999
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro
It has been suggested that DNA-dependent protein kinase (DNA-PK) is a central component of DNA double-strand-break repair. The… 
Highly Cited
1998
Highly Cited
1998
Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.
Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein… 
Highly Cited
1996
Highly Cited
1996
Nitric oxide induced poly(ADP‐ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl‐2
Highly Cited
1995
Highly Cited
1995
trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon
Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins catalyzed by poly(ADP-ribose) polymerase (PARP; EC… 
Highly Cited
1991
Highly Cited
1991
Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase.
Highly Cited
1984
Highly Cited
1984
Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus.
Highly Cited
1977
Highly Cited
1977
A putative role for nicotinamide adenine dinucleotide-promoted nuclear protein modification in the antitumor activity of N-methyl-N-nitrosourea.
Incubation of HeLa cells with the anticancer agent N-methyl-N-nitrosourea (MNU) results in: (a) depression of intracellular… 
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