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PARP1 protein, human

Known as: ADPRT 1, Poly(ADP Ribose) Polymerase, NAD(+) ADP-Ribosyltransferase 1 
Poly [ADP-ribose] polymerase 1 (1013aa, ~113 kDa) is encoded by the human PARP1 gene. This protein is involved in poly ADP-ribosylation and in the… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
While tremendous improvement has been made for the treatment of breast cancers, the treatment of triple negative breast cancer… Expand
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Review
2017
Review
2017
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome… Expand
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Review
2017
Review
2017
PARP inhibitors represent a major breakthrough in ovarian cancer care. Almost half of all ovarian cancers have deficiencies in… Expand
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Review
2017
Review
2017
Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to… Expand
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Highly Cited
2012
Highly Cited
2012
Small-molecule inhibitors of PARP are thought to mediate their antitumor effects as catalytic inhibitors that block repair of DNA… Expand
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Highly Cited
2011
Highly Cited
2011
Parkinson's disease (PD) is a progressive, neurodegenerative condition that has increasingly been linked with mitochondrial… Expand
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Highly Cited
2008
Highly Cited
2008
Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence… Expand
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Highly Cited
2007
Highly Cited
2007
This corrects the article DOI: 10.1038/nature03443 
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Highly Cited
2005
Highly Cited
2005
Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the… Expand
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Review
1997
Review
1997
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… Expand
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