Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
- P. G. Arnison, M. Bibb, W. A. van der Donk
- Biology, ChemistryNatural product reports (Print)
- 2013
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Conus venoms: a rich source of novel ion channel-targeted peptides.
- H. Terlau, B. Olivera
- BiologyPhysiological Reviews
- 2004
This review focuses on the targeting specificity of conotoxins and their differential binding to different states of an ion channel.
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.
- E. Mccleskey, A. Fox, D. Yoshikami
- BiologyProceedings of the National Academy of Sciences…
- 1 June 1987
The tissue and channel-type specificity and the directness and slow reversibility of the block are features that favor use of omega-conotoxin as a tool for purifying particular neuronal Ca2+ channels and defining their physiological function.
A new conus peptide ligand for mammalian presynaptic Ca2+ channels
- D. Hillyard, V. Monje, B. Olivera
- BiologyNeuron
- 1 July 1992
A New -Conotoxin Which Targets 32 Nicotinic Acetylcholine Receptors (*)
- G. Cartier, D. Yoshikami, W. Gray, S. Luo, B. Olivera, J. McIntosh
- Biology, ChemistryJournal of Biological Chemistry
- 29 March 1996
It is increasingly apparent that α-conotoxins represent a significant resource for ligands with which to probe structure-function relationships of various nAChR subtypes.
Targeted mutagenesis by homologous recombination in D. melanogaster.
- Y. Rong, Simon W. A. Titen, K. Golic
- BiologyGenes & Development
- 15 June 2002
It is shown that genes not near telomeres can be efficiently targeted; that no knowledge of the mutant phenotype is needed for targeting; and that insertional mutations and allelic substitutions can be easily produced.
CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE : THE OMEGA -CONOTOXINS AND OMEGA -AGATOXINS
- B. Olivera, G. Miljanich, J. Ramachandran, M. Adams
- Biology
- 1994
The level of intracellular Ca regulates many cellular processes, including neurotransmitter and hormone secretion, the activity of ion channels and enzymes, cytoskeletal function, cell proliferation,…
α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release
- S. Luo, J. M. Kulak, J. McIntosh
- Biology, ChemistryJournal of Neuroscience
- 1 November 1998
The purification and characterization of an α3β4 nAChR antagonist, α-conotoxin AuIB, from the venom of the “court cone,” Conus aulicus is described and the total chemical synthesis of this and two related peptides that were also isolated from the Venom is described.
Conus Peptides: Biodiversity-based Discovery and Exogenomics*
- B. Olivera
- BiologyJournal of Biological Chemistry
- 20 October 2006
The interdisciplinary paradigm that has evolved for the systematic discovery of Conus venom peptides, if applied more broadly, should prove fruitful for generally exploring chemical diversity from the animal biodiversity that surrounds us.
Peptide neurotoxins from fish-hunting cone snails.
- B. Olivera, W. Gray, L. Cruz
- BiologyScience
- 20 December 1985
Five new omega-conotoxins that block presynaptic calcium channels are described, and the fact that they inhibit sequential steps in neuromuscular transmission suggests that their action is synergistic rather than additive.
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