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Conus venoms: a rich source of novel ion channel-targeted peptides.
This review focuses on the targeting specificity of conotoxins and their differential binding to different states of an ion channel. Expand
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The… Expand
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle.
- E. Mccleskey, A. Fox, +4 authors D. Yoshikami
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 June 1987
The tissue and channel-type specificity and the directness and slow reversibility of the block are features that favor use of omega-conotoxin as a tool for purifying particular neuronal Ca2+ channels and defining their physiological function. Expand
A New -Conotoxin Which Targets 32 Nicotinic Acetylcholine Receptors (*)
- G. Cartier, D. Yoshikami, W. Gray, S. Luo, B. Olivera, J. McIntosh
- Chemistry, Biology
- The Journal of Biological Chemistry
- 29 March 1996
It is increasingly apparent that α-conotoxins represent a significant resource for ligands with which to probe structure-function relationships of various nAChR subtypes. Expand
A new conus peptide ligand for mammalian presynaptic Ca2+ channels
A new Conus peptide is described that is an effective inhibitor of omega-CgTx-GVIA-resistant synaptic transmission and defines a general approach for obtaining ligands with novel receptor subtype specificity from Conus. Expand
Targeted mutagenesis by homologous recombination in D. melanogaster.
It is shown that genes not near telomeres can be efficiently targeted; that no knowledge of the mutant phenotype is needed for targeting; and that insertional mutations and allelic substitutions can be easily produced. Expand
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins.
CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE : THE OMEGA -CONOTOXINS AND OMEGA -AGATOXINS
The level of intracellular Ca regulates many cellular processes, including neurotransmitter and hormone secretion, the activity of ion channels and enzymes, cytoskeletal function, cell proliferation,… Expand
α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release
Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3β4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally… Expand
Peptide neurotoxins from fish-hunting cone snails.
Five new omega-conotoxins that block presynaptic calcium channels are described, and the fact that they inhibit sequential steps in neuromuscular transmission suggests that their action is synergistic rather than additive. Expand