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Poly (ADP-Ribose) Polymerase-1

Known as: Poly (ADP-Ribose) Synthase-1, PARP-1 Protein, PARP 1 Protein 
A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin… 
National Institutes of Health

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ADP Ribose TransferasesIn BloodMono(ADP-Ribose) TransferasesNAD+ ADP-Ribosyltransferase

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Adprt protein, ratPARP1 protein, humanParp1 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
t-BuOOH induces ferroptosis in human and murine cell lines
Reactive oxygen species (ROS)-induced apoptosis has been extensively studied. Increasing evidence suggests that ROS, for instance… 
Review
2015
Review
2015
Poly(ADP)-Ribose Polymerase-1 Inhibitors as a Potential Treatment for Cocaine Addiction.
As of 2008, according to the National Survey on Drug Use and Health, nearly 1.4 million Americans met the Diagnostic and… 
2015
2015
Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3' untranslated region and their association with PARP1 expression in breast cancer patients.
Within the past several years, inhibition of the PARP1 activity has been emerged as one of the most exciting and promising… 
2015
2015
Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells
SummaryPoly (ADP-ribose) polymerase-1 (PARP-1) inhibitors and histone deacetylase (HDAC) inhibitors have recently emerged as… 
Review
2014
Review
2014
Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases
The neurotrophins (NTs) nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, and NT-4/5 are proteins that… 
2013
2013
Glucose Deprivation Converts Poly(ADP-ribose) Polymerase-1 Hyperactivation into a Transient Energy-producing Process*
Background: Excessive activation of enzyme poly(ADP-ribose) polymerase-1 (PARP-1) causes ATP depletion and kills cells. Results… 
2012
2012
Immunohisochemical study of BRCA1, BRCA2, and poly (ADP-ribose) polymerase-1 in ovarian tumors
Negative expression of BRCA1 and BRCA2 was found in 12.5% and 22.5% of benign tumors, 25.0% and 33.3% of borderline tumors, and… 
2010
2010
Poly (ADP‐ribose) polymerase‐1 binds to BCL2 major breakpoint region and regulates BCL2 expression
BCL2, originally identified as a proto‐oncogene in B‐cell lymphoma, is a key regulator of apoptosis. Although it is more than 200… 
2009
2009
Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway.
alpha-Synuclein (ASN) is a brain-enriched protein that functions as a molecular chaperone and regulator of the synaptic vesicle… 
2003
2003
Poly(ADP-ribose) polymerase-1 dimerizes at a 5' recessed DNA end in vitro: a fluorescence study.
Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is an immediate cellular reaction to DNA strand breakage as induced by… 
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