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Poly(ADP-ribose) Polymerases

Known as: Poly(ADP-Ribose) Synthase, Poly(ADPribose) Polymerase, NAD(+) ADP ribosyltransferase 
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Inhibition of poly(ADP-ribose) polymerase (PARP) activity induces synthetic lethality in mutated BRCA1/2 cancers by selectively… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… Expand
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Review
2006
Review
2006
The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs… Expand
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Highly Cited
2005
Highly Cited
2005
Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the… Expand
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Highly Cited
2002
Highly Cited
2002
Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also… Expand
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Review
1999
Review
1999
Poly(ADP-ribosyl)ation is a post-translational modification of proteins. During this process, molecules of ADP-ribose are added… Expand
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Highly Cited
1997
Highly Cited
1997
Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage… Expand
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Highly Cited
1995
Highly Cited
1995
Abstract Although the mechanism of mammalian apoptosis has not been elucidated, a protease of the CED-3/ICE family is anticipated… Expand
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Highly Cited
1994
Highly Cited
1994
RECENT studies suggest that pro teases of the inter leukin 1-β-con-verting enzyme (ICE)/ced-3 family are involved in initiating… Expand
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Highly Cited
1993
Highly Cited
1993
Apoptosis is a morphologically and biochemically distinct form of cell death that occurs under a variety of physiological and… Expand
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