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Human glutathione S-transferases.
An ortholog of rat GST 8-8 and mouse mGSTA4-4 is selectively expressed in some human tissues including bladder, brain, heart, liver, and pancreas and this isoenzyme designated as GST 5.8 expresses several fold higher activity towards 4-hydroxy-2,3-trans-nonenal as compared to the routinely used substrate 1-chloro- 2,4-dinitrobenzene. Expand
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.
Data indicate that the residue in position 104 helps to define the geometry of the hydrophobic substrate-binding site, and may also influence activity by interacting with residues directly involved in substrate binding. Expand
Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.
The results suggest that induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti-inflammatory and anti-cancer activities of curcumin. Expand
Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.
It is reported that the allelic variants of human Pi class GST (hGSTP1-1), which differ in their primary structures at amino acids in positions 104 and/or 113, exhibit significant differences in their activity in the GSH conjugation of alkylating anticancer drug thiotepa. Expand
Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.
The presence of recombinant human glutathione S-transferase(GST)P1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH and was shown to catalyze the reverse reaction leading to the formation ofCurcumin from GSH adducts of FMK and FAL. Expand
RLIP76, a non-ABC transporter, and drug resistance in epilepsy
It is concluded that RLIP76 is the predominant transporter of AED in the blood brain barrier, and that it may be a transporter involved in mechanisms of drug-resistant epilepsy. Expand
Role of Glutathione S-Transferases in Protection against Lipid Peroxidation
The physiological significance of the selenium-independent glutathione peroxidase (GPx) activity of glutathione S-transferases (GSTs), associated with the major Alpha class isoenzymes hGSTA1-1 andExpand
The role of human glutathione S-transferases hGSTA1-1 and hGSTA2-2 in protection against oxidative stress.
The results suggest that alpha-class GSTs may be involved in the reduction of 5-hydroperoxyeicosatetraenoic acid, an important intermediate in the 5-lipoxygenase pathway. Expand
Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.
The results show that 4-HNE mediates apoptosis through its effects on JNK and caspase 3, and that 4,HNE metabolizing GST isozyme(s) may be important in the regulation of this pathway of oxidative-stress-induced apoptosis. Expand
Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.
Investigations collectively provide strong evidence that VCN-2 is effective against CaP progression along with indicating that VCn-2 and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Expand