Oxotremorine

Known as: 2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-, Oxotremorine [Chemical/Ingredient], Oxytremorine 
A non-hydrolyzed muscarinic agonist used as a research tool.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (5)

Cholinergic AgentsGanglionic StimulantsMuscarinic AgonistsPyrrolidinones
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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Narrower (3)

U 80816Boxotremorine Moxotremorine sesquifumarate

Papers overview

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Highly Cited
2008
Highly Cited
2008
Cyclic and Sleep-Like Spontaneous Alternations of Brain State Under Urethane Anaesthesia
BACKGROUND Although the induction of behavioural unconsciousness during sleep and general anaesthesia has been shown to involve… (More)
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Highly Cited
2002
Highly Cited
2002
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.
Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play important roles in many fundamental… (More)
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Highly Cited
1999
Highly Cited
1999
Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.
Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be… (More)
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Highly Cited
1999
Highly Cited
1999
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice
G protein-coupled receptor kinase 5 (GRK5) is a member of a family of enzymes that phosphorylate activated G protein-coupled… (More)
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Highly Cited
1998
Highly Cited
1998
Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits.
Recent research has indicated that increased vulnerability to oxidative stress may be the major factor involved in CNS functional… (More)
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1995
1995
Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors.
cDNAs encoding for M1 and M3 muscarinic acetylcholine (ACh) receptors were detected in rat pancreatic islet cells by polymerase… (More)
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1985
1985
Tolerance, cross-tolerance, and receptors after chronic nicotine or oxotremorine
Saline, 8.0 mg/kg/hr nicotine, or 1.0 mg/kg/hr oxotremorine was continuously infused into the jugular veins of DBA female mice… (More)
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Highly Cited
1984
Highly Cited
1984
Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells
The mechanism underlying the regulation of the K-channel by the muscarinic receptor was examined with patch-clamp experiments in… (More)
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1979
1979
Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice
The immediate posttrial injection of oxotremorine (0.125, 0.250 and 0.500 μMol/kg i.p.) and equimolecular doses of physostigmine… (More)
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1972
1972
Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle.
Effects of acetylcholine and of agents that mimic or block its physiological actions have been studied upon concentrations of… (More)
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