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Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.
The present findings indicate that tetanus toxin, and possibly also the botulinum neurotoxins, are metalloproteases and that they block neurotransmitter release via this protease activity. Expand
A role for the interchain disulfide or its participating thiols in the internalization of botulinum neurotoxin A revealed by a toxin derivative that binds to ecto-acceptors and inhibits transmitter
The abolition of the toxicity of extracellularly applied botulinum neurotoxin A by the cleavage of both disulfides, and the alkylation of the half-cystines involved, results from ineffective uptake. Expand
Site of Origin and Propagation of Spike in the Giant Neuron of Aplysia
  • L. Tauc
  • Biology, Medicine
  • The Journal of general physiology
  • 1 July 1962
Evidence was obtained that under normal conditions of excitability, the spike originates at some distance from the soma in an axonal region with a higher excitability surpassing that of the surrounding membranes. Expand
Minimal essential domains specifying toxicity of the light chains of tetanus toxin and botulinum neurotoxin type A.
This finding suggests that the HC domain of the H chain becomes exposed to the cytosol during or after the putative translocation step of the L chain, which is linked to the carboxyl-terminal portion of theH chain. Expand
Botulinum and Tetanus Neurotoxins
Chlorpromazine increased the phosphorylated state of a number of phosphoproteins with apparent molecular weights (MrS) between 40 and 60 kilodaltons and was inhibited in a concentration and temperature-dependent manner. Expand
Anomalous rectification in the metacerebral giant cells and its consequences for synaptic transmission
1. In the central neurones that have so far been examined the passive electrical properties of the extrasynaptic membrane has been shown to be relatively constant in the subthreshold range.Expand
Heterosynaptic facilitation in neurones of the abdominal ganglion of Aplysia depilans.
This paper and the one that follows describe an attempt to apply a heterosynaptic stimulus sequence, analogous to that used in psychological learning experiments, to a numerically simple and simple stimulus system. Expand
Modes of Initiation and Propagation of Spikes in the Branching Axons of Molluscan Central Neurons
Observations of the presence of different sizes of A spikes produced by orthodromic stimulation provide evidence that spikes initiated at separate axonal "trigger zones" of Aplysia neurons may be conducted selectively to the effectors or other neurons innervated by the particular branch. Expand
Electrical Transmission among Neurons in the Buccal Ganglion of a Mollusc, Navanax inermis
The opisthobranch mollusc, Navanax, is carnivorous and cannibalistic, and electrical coupling among the 10 cells plays a minor role in sudden pharyngeal contractions but that the dual electrical-chemical coupling with interneurons may be important in this respect. Expand