• Publications
  • Influence
Modulation of paraoxonase (PON1) activity.
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein (HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as well as nerve agents; itExpand
  • 424
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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins (HDLs) in the plasma; it is involved in the detoxification of organophosphate insecticides such as parathionExpand
  • 1,034
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Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor
Xestospongins (Xe's) A, C, D, araguspongine B, and demethylxestospongin B, a group of macrocyclic bis-1-oxaquinolizidines isolated from the Australian sponge, Xestospongia species, are shown to beExpand
  • 533
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Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment
This review examines the large body of toxicological and epidemiological information on human exposures to chlorpyrifos, with an emphasis on the controversial potential for chlorpyrifos to induceExpand
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Current issues in organophosphate toxicology.
  • L. Costa
  • Biology, Medicine
  • Clinica chimica acta; international journal of…
  • 1 April 2006
Organophosphates (OPs) are one of the main classes of insecticides, in use since the mid 1940s. OPs can exert significant adverse effects in non-target species including humans. Because of theExpand
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Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants.
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants used in a variety of consumer products. In the past 25 years, PBDEs have become ubiquitous environmental contaminants. They haveExpand
  • 505
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Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
This review examines the large body of toxicological and epidemiological information on human exposures to chlorpyrifos, with an emphasis on the controversial potential for chlorpyrifos to induceExpand
  • 165
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Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development.
Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are extensively diffused in the environment as shown by several studies on sentinel animal species, as well as humans.Expand
  • 212
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Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects.
Polybrominated diphenyl ethers (PBDEs) are an important class of flame retardants, widely used in a variety of consumer products. In the past several years, PBDEs have become widespread environmentalExpand
  • 267
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Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity.
Organophosphorus (OP) compounds are still among the most widely used insecticides, and their main mechanism of acute toxicity is associated with inhibition of acetylcholinesterase. Measurements ofExpand
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