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Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
RationaleNicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments forExpand
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Cognitive effects of nicotine
Nicotine and other nicotinic agonists have been found to improve performance on attention and memory tasks. Clinical studies using nicotine skin patches have demonstrated the efficacy of nicotine inExpand
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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats
RationaleA few recent studies suggest that brain histamine levels and signaling via H3 receptors play an important role in modulation of alcohol stimulation and reward in rodents.ObjectiveThe presentExpand
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Antidepressant effects of nicotine in an animal model of depression
Abstract Epidemiological studies indicate a high incidence of cigarette smoking among depressed individuals. Moreover, individuals with a history of depression have a much harder time giving upExpand
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Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression
The effects of acute and chronic stressors on saccharin intake and preference in the hypercholinergic Flinders Sensitive Line (FSL) rat, a putative genetic animal model of depression, were studiedExpand
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Adolescent-onset nicotine self-administration modeled in female rats
RationaleAlthough the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults.ObjectivesA rat model was used toExpand
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Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.
People with schizophrenia often have substantial cognitive impairments, which may be related to nicotinic receptor deficits, (alpha7 and alpha4beta2), documented in the brains of people withExpand
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Nicotinic α7- or β2-containing receptor knockout: Effects on radial-arm maze learning and long-term nicotine consumption in mice
Classically, it has been thought that high-affinity nicotinic receptors-containing beta2 subunits are the most important receptor subtypes for nicotinic involvement in cognitive function and nicotineExpand
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Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.
Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn-Hooded (FH), alcohol-preferring (P) and Maudsley Reactive rats haveExpand
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Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.
Adolescence is the life stage when tobacco addiction typically begins. Adolescent neurobehavioral development may be altered by nicotine self-administration in a way that persistently potentiatesExpand
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