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International Union of Pharmacology. XXXIII. Mammalian γ-Aminobutyric AcidB Receptors: Structure and Function
The emergence of high-affinity antagonists for GABAB receptors has enabled a synaptic role to be established, however, the antagonists have generally failed to establish the existence of pharmacologically distinct receptor types within the GABAB receptor class.
Synaptosomes Still Viable after 25 Years of Superfusion
The major aim of the article is to draw attention on the versatility of superfused synaptosomes and to suggest how the system could be exploited in clarifying several aspects of synaptic neurochemistry including neurotransmitter transport, receptor localization, receptor-receptor interactions, functional aspects of multi-sited receptor complexes, receptor heterogeneity and mechanisms of neurotransmitter exocytosis-endocythesis.
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.
The gamma-aminobutyric acid(B) (GABA(B)) receptor was first demonstrated on presynaptic terminals where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter release by…
A simple apparatus for studying the release of neurotransmitters from synaptosomes.
Direct evidence that release‐stimulating α7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals
- M. Marchi, Francesca Risso, C. Viola, P. Cavazzani, M. Raiteri
- Biology, ChemistryJournal of neurochemistry
- 1 March 2002
Glutamatergic axon terminals in human neocortex and in rat striatum possess α7* nicotinic heteroreceptors mediating enhancement of glutamate release, which are nAChRs with a pharmacological profile compatible with the α4β2 subunit combination.
Carrier-mediated release of neurotransmitters
Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine.
Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.
Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease
Results indicate that the beneficial effect of DBS in PD patients is paralleled with a stimulus‐synchronized activation of the STN target, SNr, and suggest that, during STN‐DBS, a critical change towards a high‐frequency oscillatory discharge occurs.
Cyclo‐oxygenase‐1 and ‐2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N‐methyl‐d‐aspartate receptors in rat hippocampus
The data suggest that, although COX‐2 is the prominent isoform,COX‐1 activity may significantly contribute to excitotoxicity, particularly when considering the amount of lipid peroxidation associated with its catalytic cycle.