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The flinders sensitive line rats: A genetic animal model of depression
  • D. Overstreet
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1 March 1993
The Flinders Sensitive Line (FSL) rat, selectively bred for increased responses to the anticholinesterase DFP, was originally proposed as an animal model of depression because, like depressed humans,Expand
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The Flinders Sensitive Line rat: A selectively bred putative animal model of depression
The Flinders Sensitive Line (FSL) rats were originally selectively bred for increased responses to an anticholinesterase agent. The FSL rat partially resembles depressed individuals because itExpand
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High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment.
Although alterations in serotonin levels and neurotransmission are associated with depressive disorders and effective antidepressant therapy, the exact cause of these disorders and the mode of actionExpand
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The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
RationaleRecent research indicates that blockade of mGluR5 modifies the reinforcing properties of ethanol.ObjectivesThe present studies examined the effects of mGluR5 receptor blockade in a geneticExpand
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The Flinders Sensitive Line Rat Model of Depression—25 Years and Still Producing
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats wasExpand
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Stress enhancement of craving during sobriety: a risk for relapse.
  • G. Breese, K. Chu, +10 authors F. Weiss
  • Psychology, Medicine
  • Alcoholism, clinical and experimental research
  • 1 February 2005
This report of the proceedings of a symposium presented at the 2004 Research Society on Alcoholism Meeting provides evidence linking stress during sobriety to craving that increases the risk forExpand
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Modeling depression in animal models.
Animal models and preclinical tests have played large roles in the development of antidepressant drugs and are likely to continue to play important roles. In the present communication, the mainExpand
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Antidepressant effects of nicotine in an animal model of depression
Abstract Epidemiological studies indicate a high incidence of cigarette smoking among depressed individuals. Moreover, individuals with a history of depression have a much harder time giving upExpand
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Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression
Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression. InExpand
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Conceptual framework for the etiology of alcoholism: a “kindling”/stress hypothesis
RationaleThe rationale for proposing the “kindling”/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse.Objective and resultsAn objectiveExpand
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