Oseltamivir

Known as: Oseltamivir [Chemical/Ingredient], (-)-oseltamivir, 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))- 
A synthetic derivative prodrug of ethyl ester with antiviral activity. Osetamivir blocks neuraminidases on the surfaces of influenza viruses… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The His274-->Tyr274 (H274Y) mutation confers oseltamivir resistance on N1 influenza neuraminidase but had long been thought to… (More)
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Highly Cited
2009
Highly Cited
2009
953 S from one influenza season to the next, we have lost the use of our leading antiviral influenza drug because of resistance… (More)
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Highly Cited
2009
Highly Cited
2009
In Norway in January 2008, unprecedented levels of oseltamivir resistance were found in 12 of 16 influenza viruses A (H1N1… (More)
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Highly Cited
2009
Highly Cited
2009
To the Editor: Neuraminidase inhibitors (osel­ tamivir and zanamivir) are recommended for treat­ ment of severe illness caused by… (More)
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Highly Cited
2008
Highly Cited
2008
The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public… (More)
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Highly Cited
2005
Highly Cited
2005
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was… (More)
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Review
2005
Review
2005
Recent cross species transmission of avian influenza has highlighted the threat of pandemic influenza. Oseltamivir (Tamiflu) has… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Influenza causes lower respiratory tract complications (LRTCs), particularly bronchitis and pneumonia, in both… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Oral oseltamivir administration is effective treatment for influenza in adults. This study was conducted to determine… (More)
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Highly Cited
1999
Highly Cited
1999
CONTEXT Influenza virus neuraminidase is thought to be essential for virus replication in humans; however, to date, available… (More)
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