Tamiflu
National Institutes of Health
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We have developed a novel oseltamivir derivative (oseltamivir hexylthiol; OHT) that exhibits a higher binding affinity for…
Oseltamivir is the most common antiviral drug used to treat and prevent influenza. Epidemiological studies performed in Japan…
We’re continuing to mark the 20 years since The BMJ launched itself on the internet. In 1995, with the then web editor, Tony…
Recent epidemiological developments demonstrated that gene segments of swine influenza A viruses can account for antigenic…
Tamiflu, also known as oseltamivir (OTV), binds to influenza A neuraminidase (H5N1) with very high affinity (0.32 nM). However…
Oseltamivir phosphate (Tamiflu) has been synthesized from cis-2,3-bis(hydroxymethyl)aziridine. After protection of the cis-2,3…
A molecular model of the swine influenza A/H1N1 ( also called H1N1pdm) type-I neuraminidase was built using the pathogenic avian…
Catalytic asymmetric synthesis of Tamiflu, an important antiinfluenza drug, was achieved. After the catalytic enantioselective…
Promising results raise hopes in the battle against AIDS.