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Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, Rac
Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux
It is suggested that Ro 64-0802 can cross the BBB from the blood, but its brain distribution is limited by its active efflux by Mrp4 and Oat3 across theBBB.
P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier
The results suggest that P-gp limits the brain uptake of oseltamivir at the blood-brain barrier (BBB) and that Ro 64-0802 itself barely crosses the BBB.
Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-Mediated Lysophosphatidic Acid Signaling in Mice1
The results suggest that LPA3 signaling controls embryo spacing via uterine contraction around E3.5, which is critical for embryo spacing.
Stimulating Concepts in Chemistry
Design and synthesis - theozymes and catalyst design organic synthesis in aqueous media domino reactions asymmetric two-center catalysis organic reactions in supercritical CO2 separation-built-in
An enantioselective formal synthesis of 4-demethoxydaunomycin using the catalytic asymmetric ring opening reaction of meso-epoxide with p-anisidine
Abstract A catalytic asymmetric formal synthesis of 4-demethoxydaunomycin ( 3 ) was achieved using a catalytic asymmetric ring opening reaction of meso-epoxide 9 as a key step. The epoxide opening
Second generation catalytic asymmetric synthesis of Tamiflu: allylic substitution route.
This second generation route of Tamiflu is more practical than the previously reported route and introduces an allylic oxygen function and C1 unit on the C=C double bond through cyanophosphorylation of enone and allylic substitution with an oxygen nucleophile.
Dynamic ligand exchange of the lanthanide complex leading to structural and functional transformation: one-pot sequential catalytic asymmetric epoxidation-regioselective epoxide-opening process.
The in situ IR spectroscopy and other experiments provided strong evidence that the samarium azide complex was generated, and the relatively high Lewis basicity of the amide moiety had a key role in the high reactivity of both the epoxidation and the epoxide-opening reactions.
Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.
The indenotryptoline bisindole alkaloid was synthesised using osmium-promoted cis-dihydroxylation of maleimide as a key step and induced apoptosis of epidermal growth factor (EGF)-stimulated EGF receptor overexpressing A431 cells and inhibited vacuolar-type H(+)-ATPase (V- ATPase).
Basic character of rare earth metal alkoxides. Utilization in catalytic C-C bond-forming reactions and catalytic asymmetric nitroaldol reactions
In a recent paper, the authors reported that Zr(O-t-Bu){sub 4} was an efficient and convenient basic reagent in organic synthesis. However, all reactions examined were performed with stoichiometric