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The changing and dynamic epidemiology of meningococcal disease.
TLDR
The imminent availability of recombinant broadly protective serogroups B vaccines may provide the tools for further control of invasive meningococcal disease in areas where serogroup B disease predominates. Expand
Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline
TLDR
A clinical practice guideline, based on systematic reviews of the literature, as interpreted by experts, to assist clinicians in managing procedure-related pain and distress among children undergoing vaccine injections is developed. Expand
Pertussis of adults and infants.
TLDR
Vaccine-recommending bodies and national health-care organisations must have locally relevant information on the transmission of pertussis from adults to infants to be able to make decisions on the advisability, feasibility, and priority for booster immunisation against pertussedis. Expand
Morbidity of pertussis in adolescents and adults.
TLDR
Pertussis in secondary case patients was less severe than in index case patients but presented with classic symptoms, and the burden of disease appears to increase with age, with smoking, and with asthma. Expand
Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers.
TLDR
On the basis of epidemiological data demonstrating that the majority of cases of pharyngitis, necrotizing fasciitis, and other invasive streptococcal infections are caused by a limited number of serotypes, this 26-valent vaccine could have significant impact on the overall burden of streptitiscal disease. Expand
The changing age and seasonal profile of pertussis in Canada.
TLDR
Recent changes in the childhood immunization program, waning immunity, and changes in laboratory methods are considered in explaining these 2 simultaneous but divergent trends in the pertussis profile. Expand
Inadequate pain management during routine childhood immunizations: the nerve of it.
TLDR
Treating pain during childhood immunization has the potential to reduce distress during the procedure and greatly improve satisfaction with the immunization experience through more positive experiences for children and their families. Expand
Epidemiological features of pertussis in hospitalized patients in Canada, 1991-1997: report of the Immunization Monitoring Program--Active (IMPACT).
TLDR
Pertussis continues to cause significant morbidity and occasional mortality in Canada, particularly in young infants, and intensive care was required more frequently in infants under <6 months of age than in those > or =6 months. Expand
Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
TLDR
Among girls who received 2 doses of HPV vaccine 6 months apart, responses to HPV-16 and HPV-18 one month after the last dose were noninferior to those among young women who received 3 doses of the vaccine within 6 months. Expand
A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant.
TLDR
It is concluded that 1018 ISS+HBsAg was well tolerated and immunogenic in this phase I study in healthy adults and may offer the potential for enhancement of hepatitis B virus immunization and protection after one or two doses or in individuals who fail to respond to the standard vaccine regimen. Expand
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