P. Palese

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A novel influenza A virus mitochondrial protein that induces cell death

Weisan Chen, Paul A. Calvo, +10 authors Jonathan W. Yewdell
Nature Medicine
2001

While searching for alternative reading-frame peptides encoded by influenza A virus that are recognized by CD8+ T cells, we found an abundant immunogenic peptide encoded by the +1 reading frame of… (More)

Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.

Adolfo García-Sastre, Andrej Y. Egorov, +5 authors Thomas Muster
Virology
1998

The NS1 protein is the only nonstructural protein encoded by influenza A virus. It has been proposed that the NS1 performs several regulatory functions during the viral replication cycle, including… (More)

Influenza Virus Transmission Is Dependent on Relative Humidity and Temperature

Anice C Lowen, Samira Mubareka, J. Steel, P. Palese
PLoS pathogens
2007

Using the guinea pig as a model host, we show that aerosol spread of influenza virus is dependent upon both ambient relative humidity and temperature. Twenty experiments performed at relative… (More)

Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

Jean-Yves Talon, Curt M Horvath, +4 authors Adolfo García-Sastre
Journal of virology
2000

We present a novel mechanism by which viruses may inhibit the alpha/beta interferon (IFN-alpha/beta) cascade. The double-stranded RNA (dsRNA) binding protein NS1 of influenza virus is shown to… (More)

Human Host Factors Required for Influenza Virus Replication

Renate König, Silke Stertz, +23 authors Sumit K. Chanda
Nature
2010

Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many aspects of its life cycle. Knowledge of… (More)

The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins.

Robert E O'neill, Jean-Yves Talon, P. Palese
The EMBO journal
1998

Nuclear import and export of viral nucleic acids is crucial for the replication cycle of many viruses, and elucidation of the mechanism of these steps may provide a paradigm for understanding general… (More)

Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon.

Xuemei Wang, Mengtao Li, +4 authors Adolfo García-Sastre
Journal of virology
2000

The alpha/beta interferon (IFN-alpha/beta) system represents one of the first lines of defense against virus infections. As a result, most viruses encode IFN antagonistic factors which enhance viral… (More)

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

David J Dilillo, Gene S. Tan, P. Palese, Jeffrey V Ravetch
Nature Medicine
2014

Neutralizing antibodies against influenza viruses have traditionally been thought to provide protection exclusively through their variable region; the contributions of mechanisms conferred by the Fc… (More)

Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing.

Wan-Xiang Li, Hongwei Li, +9 authors Shou-Wei Ding
Proceedings of the National Academy of Sciences…
2004

Homology-dependent RNA silencing occurs in many eukaryotic cells. We reported recently that nodaviral infection triggers an RNA silencing-based antiviral response (RSAR) in Drosophila, which is… (More)

The biology of influenza viruses.

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure ofthe influenza… (More)

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