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Okadaic Acid

Known as: Acid, Ocadaic, Acid, Okadaic, OKA 
A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 &amp… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (4)

7-deoxyokadaic acidbelizeanic acidcorozalic acidokadaic acid diol ester

Broader (9)

CarcinogensEnzyme InhibitorsEthersEthers, Cyclic
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
aPKC Acts Upstream of PAR-1b in Both the Establishment and Maintenance of Mammalian Epithelial Polarity
Highly Cited
1998
Highly Cited
1998
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.
The hydrophilic bile salt ursodeoxycholic acid (UDCA) protects against the membrane-damaging effects associated with hydrophobic… 
Highly Cited
1997
Highly Cited
1997
Differential Inhibition and Posttranslational Modification of Protein Phosphatase 1 and 2A in MCF7 Cells Treated with Calyculin-A, Okadaic Acid, and Tautomycin*
Calyculin-A (CA), okadaic acid (OA), and tautomycin (TAU) are potent inhibitors of protein phosphatases 1 (PP1) and 2A (PP2A) and… 
Highly Cited
1994
Highly Cited
1994
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
Highly Cited
1993
Highly Cited
1993
An essential role for protein phosphatases in hippocampal long-term depression.
The effectiveness of long-term potentiation (LTP) as a mechanism for information storage would be severely limited if processes… 
Highly Cited
1992
Highly Cited
1992
Regulation of the cdc25 protein during the cell cycle in Xenopus extracts
Highly Cited
1992
Highly Cited
1992
Ceramide stimulates a cytosolic protein phosphatase.
Highly Cited
1989
Highly Cited
1989
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
Okadaic acid is a polyether derivative of 38-carbon fatty acid1, and is implicated as the causative agent of diarrhetic shellfish… 
Highly Cited
1989
Highly Cited
1989
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues
Highly Cited
1988
Highly Cited
1988
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.
Okadaic acid is a polyether compound of a C38 fatty acid, isolated from a black sponge, Halichondria okadai. Previous studies… 
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