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A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
TLDR
A novel synthetic peptide AIP, a nonphosphorylatable analog of autocamtide-2, was found to be a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II) and indicates that AIP is a useful tool for studying the physiological roles of CaM-Kinase II. Expand
Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin‐dependent protein kinase II
TLDR
An AIP analog, in which Ala3 and Val10 were replaced with Lys and Phe, respectively, showed an IC50 value as low as 4 nM, suggesting that it is a useful tool for studying the physiological roles of CaMKII. Expand
Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway
TLDR
Results suggest that selective estrogen-receptor modulators could represent a novel therapeutic strategy for disorders of the central nervous system based on their ability to suppress neuroinflammation through an ER-mediated transcription pathway. Expand
Stabilization of Calmodulin-dependent Protein Kinase II through the Autoinhibitory Domain (*)
TLDR
The autoinhibitory domain appears to play a crucial role in keeping the enzyme stable by binding to the substrate-binding site for the autophosphorylation site of CaM kinase II. Expand
Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology.
TLDR
Pharmacological implications for neuronal functions including memory and neuronal cell death are discussed from the viewpoint that regulation of protein kinase activity can be elucidated by focusing on protein phosphatases involved in its "switch off" mechanism. Expand
Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression
TLDR
It is suggested that C CDC26 controls growth of myeloid leukemia cells through regulation of KIT expression, and a KIT inhibitor might be an effective treatment against the forms of AML in which CCDC26 is altered. Expand
A Novel Protein Phosphatase That Dephosphorylates and Regulates Ca2+/Calmodulin-dependent Protein Kinase II*
TLDR
CaMKIIPase appears to be a specialized protein phosphatase for the regulation of CaMKII, which has shown apparent molecular weights of 54,000 and 65,000, on SDS-polyacrylamide gel electrophoresis and gel-filtration analysis. Expand
Phosphorylation of Rabphilin-3A by calmodulin-dependent protein kinase II.
TLDR
Results suggest that the CaMKII-catalyzed phosphorylation of Rabphilin-3A may modulate neurotransmitter release. Expand
Calcium- and calmodulin-dependent phosphorylation of AMPA type glutamate receptor subunits by endogenous protein kinases in the post-synaptic density.
TLDR
Ca2+/calmodulin-dependent phosphorylation of glutamate receptor may be a mechanism underlying enhanced post-synaptic receptor responsiveness in LTP. Expand
Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury.
TLDR
Astrocytes synthesize and release NGF and BDNF in response to MeHg to protect neurons from MeHG toxicity, and this study is considered to show a novel defense mechanism against Mehg-induced neurotoxicity. Expand
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