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Long-term potentiation--a decade of progress?
A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus. Expand
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
The transient suppression of GABA-mediated transmission that follows depolarization of hippocampal pyramidal neurons is mediated by retrograde signalling through release of endogenous cannabinoids, indicating that the function of endogenous cannabinoid released by depolarized hippocampal neurons might be to downregulate GABA release. Expand
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA receptors on cerebellar granule cells, and expression of a mutant stargazin lacking the PDZ-binding domain in hippocampal pyramidal cells disrupts synaptic AMPA receptor receptors, indicating that st argazin-like mechanisms for targeting AM PA receptors may be widespread in the central nervous system. Expand
Distinct short-term plasticity at two excitatory synapses in the hippocampus.
- Paul Antoine Salin, M. Scanziani, R. Malenka, R. Nicoll
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 12 November 1996
The results indicate that the mossy fiber synapse is able to integrate granule cell spiking activity over a broad range of frequencies, and this dynamic range is substantially reduced by long-term potentiation. Expand
A Cortical Circuit for Gain Control by Behavioral State
These findings establish a cortical circuit for the enhancement of visual response by locomotion and provide a potential common Circuit for the modulation of sensory processing by behavioral state. Expand
Evidence for silent synapses: Implications for the expression of LTP
It is demonstrated that it is possible to stimulate synapses that yield no detectable excitatory postsynaptic currents (EPSCs) when the cell is held at -60 mV; yet at positive holding potentials, EPSCs can be elicited that are completely blocked by the NMDAR antagonist, D-APV. Expand
Synaptic plasticity at hippocampal mossy fibre synapses
Recent work from several laboratories on the various forms of synaptic plasticity at hippocampal mossy fibre synapses conclude that these contacts have just begun to reveal their many secrets. Expand
PSD-95 involvement in maturation of excitatory synapses.
- A. El-Husseini, E. Schnell, D. Chetkovich, R. Nicoll, D. Bredt
- Biology, Medicine
- 17 November 2000
It is found that overexpression of PSD-95 in hippocampal neurons can drive maturation of glutamatergic synapses and this results demonstrate that PSd-95 can orchestrate synaptic development and are suggestive of roles for PSD -95 in synapse stabilization and plasticity. Expand
Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells
Findings indicate that NMDAR-LTD and mGluR-L TD are mechanistically distinct forms of synaptic plasticity. Expand
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
It is suggested that AMPARs, but not NMDARs, cycle into and out of the synaptic membrane at a rapid rate and that certain forms of synaptic plasticity may utilize this dynamic process. Expand