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Nucleotide Biosynthesis
Known as:
nucleotide biosynthetic process
, Nucleotide Synthesis Alteration
, nucleotide anabolism
Â
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The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an…Â
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National Institutes of Health
Topic mentions per year
Topic mentions per year
1951-2018
0
20
40
1951
2017
Related topics
Related topics
33 relations
5-Hydroxytryptamine Receptor 2C, human
ATIC gene
ATIC wt Allele
ATP5B gene
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Narrower (1)
nucleoside kinase activity
Related mentions per year
Related mentions per year
1950-2018
1960
1980
2000
2020
Nucleotide Biosynthesis
Nucleotide Metabolism
Amidophosphoribosyltransferase
NADP-Dependent Malic Enzyme
5-Hydroxytryptamine Receptor 2C, human
Serine Hydroxymethyltransferase, Cytosolic
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
John T. Cunningham
,
Melissa V. Moreno
,
Alessia Lodi
,
Sabrina M. Ronen
,
Davide Ruggero
Cell
2014
Cancer cells must integrate multiple biosynthetic demands to drive indefinite proliferation. How these key cellular processes…Â
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Highly Cited
2011
Highly Cited
2011
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
A. Bester
,
Maayan Roniger
,
+7 authors
Batsheva Kerem
Cell
2011
Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication…Â
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2000
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
Zhiwei Ma
,
Jan Cools
,
+8 authors
S. W. Morris
Blood
2000
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that…Â
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1996
1996
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.
X. Xu
,
Josh Williams
,
Hui Gong
,
Alan P Finnegan
,
Anita S Chong
Biochemical pharmacology
1996
Previous studies have demonstrated that the active metabolite of leflunomide, A77 1726 [N-(4-trifluoromethylphenyl-2-cyano-3…Â
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1995
1995
Leflunomide interferes with pyrimidine nucleotide biosynthesis
Holly M Cherwinski
,
Noelene E. Byars
,
Steve J Ballaron
,
Genki Nakano
,
J. M. Young
,
John T Ransom
Inflammation Research
1995
Leflunomide is an anti-inflammatory and immunosuppressive agent which blocks proliferation of transformed cells and mitogen…Â
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1987
1987
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.
Daniel J. Ebbole
,
Howard Zalkin
The Journal of biological chemistry
1987
An approximately 16-kilobase pair region of the Bacillus subtilis chromosome at 55 degrees containing genes for de novo purine…Â
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1983
1983
Effects of Thidiazuron on Cytokinin Autonomy and the Metabolism of N-(Delta-Isopentenyl)[8-C]Adenosine in Callus Tissues of Phaseolus lunatus L.
S C Capelle
,
D. W. S. Mok
,
Sebastian Kirchner
,
Machteld C. Mok
Plant physiology
1983
The effects of a highly cytokinin-active urea derivative, N-phenyl-N'-1,2,3-thiadiazol-5-ylurea (Thidiazuron), and zeatin on…Â
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Highly Cited
1981
Highly Cited
1981
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
Richard C. Mulligan
,
Pauline van den Berg
Proceedings of the National Academy of Sciences…
1981
Cultured monkey (TC7) and mouse (3T6) cells synthesize an Excherichia coli enzyme, xanthine-guanine phosphoribosyltransferase…Â
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Highly Cited
1979
Highly Cited
1979
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
E J Cadman
,
Robert Heimer
,
Leigh Davis
Science
1979
Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a…Â
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1978
1978
Stimulation of myocardial adenine nucleotide biosynthesis by pentoses and pentitols
H L Zimmer
,
Eckehart Gerlach
Pflügers Archiv
1978
In rats, pentoses and pentitols, intravenously injected in a single dose of 100 mg/kg, induced a considerable enhancement of the…Â
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