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Nucleotide Biosynthesis

Known as: nucleotide biosynthetic process, Nucleotide Synthesis Alteration, nucleotide anabolism 
The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
0204019512017

Related topics

Related topics

33 relations
5-Hydroxytryptamine Receptor 2C, humanATIC geneATIC wt AlleleATP5B gene
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Narrower (1)

nucleoside kinase activity

Related mentions per year

Related mentions per year

1950-2018
1960198020002020
Nucleotide Biosynthesis
Nucleotide Metabolism
Amidophosphoribosyltransferase
NADP-Dependent Malic Enzyme
5-Hydroxytryptamine Receptor 2C, human
Serine Hydroxymethyltransferase, Cytosolic

Papers overview

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2014
2014
Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
Cancer cells must integrate multiple biosynthetic demands to drive indefinite proliferation. How these key cellular processes… (More)
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Highly Cited
2011
Highly Cited
2011
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
Chromosomal instability in early cancer stages is caused by stress on DNA replication. The molecular basis for replication… (More)
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2000
2000
Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide…
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that… (More)
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1996
1996
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.
Previous studies have demonstrated that the active metabolite of leflunomide, A77 1726 [N-(4-trifluoromethylphenyl-2-cyano-3… (More)
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1995
1995
Leflunomide interferes with pyrimidine nucleotide biosynthesis
Leflunomide is an anti-inflammatory and immunosuppressive agent which blocks proliferation of transformed cells and mitogen… (More)
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1987
1987
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.
An approximately 16-kilobase pair region of the Bacillus subtilis chromosome at 55 degrees containing genes for de novo purine… (More)
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1983
1983
Effects of Thidiazuron on Cytokinin Autonomy and the Metabolism of N-(Delta-Isopentenyl)[8-C]Adenosine in Callus Tissues of Phaseolus lunatus L.
The effects of a highly cytokinin-active urea derivative, N-phenyl-N'-1,2,3-thiadiazol-5-ylurea (Thidiazuron), and zeatin on… (More)
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Highly Cited
1981
Highly Cited
1981
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.
Cultured monkey (TC7) and mouse (3T6) cells synthesize an Excherichia coli enzyme, xanthine-guanine phosphoribosyltransferase… (More)
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Highly Cited
1979
Highly Cited
1979
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
Exposure of L1210 leukemia cells first to 0.1 to 100 micromolar methotrexate and then to 10 micromolar 5-fluorouracil produces a… (More)
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1978
1978
Stimulation of myocardial adenine nucleotide biosynthesis by pentoses and pentitols
In rats, pentoses and pentitols, intravenously injected in a single dose of 100 mg/kg, induced a considerable enhancement of the… (More)
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