ATIC gene

Known as: AICAR TRANSFORMYLASE/IMP CYCLOHYDROLASE, IMPCHASE, 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase Gene 
This gene plays a role in purine biosynthesis.
National Institutes of Health

Papers overview

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2011
2011
OBJECTIVES Methotrexate (MTX) is the mainstay treatment for juvenile idiopathic arthritis (JIA), however approximately 30% of… (More)
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Highly Cited
2008
Highly Cited
2008
EML4-ALK gene fusions have recently been discovered in a subset of human lung carcinomas, and fusions of the ALK tyrosine kinase… (More)
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2008
2008
Taking into account spins, we classify all two-body non-relativistic Dark Matter annihilation channels to the allowed… (More)
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Highly Cited
2007
Highly Cited
2007
The interconversion of folates by the one-carbon metabolism pathway is essential for the synthesis of precursors used in DNA… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Methotrexate (MTX) enters cells through the reduced folate carrier (RFC-1) and exerts part of its effects through… (More)
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Highly Cited
2003
Highly Cited
2003
Many important virulence genes of pathogenic bacteria are preferentially expressed in vivo. We used the recently developed in… (More)
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Highly Cited
2000
Highly Cited
2000
The subset of CD30-positive anaplastic large cell lymphomas (ALCL) with the NPM-ALK gene fusion arising from the t(2;5)(p23;q35… (More)
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Highly Cited
2000
Highly Cited
2000
The non-Hodgkin lymphoma (NHL) subtype anaplastic large-cell lymphoma (ALCL) is frequently associated with a t(2;5)(p23;q35) that… (More)
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Highly Cited
2000
Highly Cited
2000
Anaplastic lymphoma kinase (ALK)-positive lymphomas ("ALKomas") constitute a distinct molecular and clinicopathological entity… (More)
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1998
1998
The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reductase… (More)
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