FAQ

ATIC wt Allele

Known as: IMPCHASE, Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase Gene, AICAR 
Human ATIC wild-type allele is located in the vicinity of 2q35 and is approximately 38 kb in length. This allele, which encodes bifunctional purine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
01219892017

Related topics

Related topics

4 relations
2q35ATIC geneHydrolysisNucleotide Biosynthesis

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
ATIC wt Allele
Nucleotide Biosynthesis
Hydrolysis
2q35
ATIC gene

Papers overview

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2018
2018
Analysis of substrate binding in individual active sites of bifunctional human ATIC.
Aminoimidazolecarboxamide ribonucleotide formyl transferase (AICARFT): Inosine monophosphate cyclohydrolase (IMPCH, collectively… (More)
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2017
2017
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4…
A hallmark of cancer is unbridled proliferation that can result in increased demand for de novo synthesis of purine and… (More)
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2013
2013
Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma.
BACKGROUND Malignant mesothelioma is a highly aggressive tumor arising from mesothelial-lined surfaces, most often in the pleura… (More)
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2009
2009
Phylogenomics and protein signatures elucidating the evolutionary relationships among the Gammaproteobacteria.
The class Gammaproteobacteria, which forms one of the largest groups within bacteria, is currently distinguished from other… (More)
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2005
2005
Genetic requirements for potassium ion-dependent colony spreading in Bacillus subtilis.
Undomesticated strains of Bacillus subtilis exhibit extensive colony spreading on certain soft agarose media: first the formation… (More)
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2000
2000
Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line.
It has been proposed that the clinical utility of methotrexate (MTX) in the treatment of rheumatoid arthritis may be due, in part… (More)
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2000
2000
Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo.
Regulated alternative splicing of avian cardiac troponin T (cTNT) pre-mRNA requires multiple intronic elements called muscle… (More)
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1996
1996
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping.
We report here the cloning and sequencing of the cDNA, purification, steady state kinetic analysis, and truncation mapping… (More)
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1995
1995
The stereospecific cytotoxic potency of (6R) and (6S)-5,10- dideazatetrahydrofolate correlates with cellular folylpolyglutamate synthetase levels.
The de novo purine synthesis inhibitor 5,10-dideazatetrahydrofolate (DDATHF) has previously been shown to inhibit the growth of… (More)
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1989
1989
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
In order to determine the biochemical basis for the cytotoxicity of homofolates, poly-gamma-glutamyl derivatives of homofolate… (More)
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