Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.

@article{Thorndike1989InhibitionOG,
  title={Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.},
  author={Janet Thorndike and Y Gaumont and Roy L. Kisliuk and Francis M. Sirotnak and Bellana S. R. Murthy and Muraleedharan G Nair and James R Piper},
  journal={Cancer research},
  year={1989},
  volume={49 1},
  pages={158-63}
}
In order to determine the biochemical basis for the cytotoxicity of homofolates, poly-gamma-glutamyl derivatives of homofolate (HPteGlu) and tetrahydrohomofolate (H4HPteGlu) were synthesized and tested as inhibitors of glycinamide ribonucleotide formyltransferase (GARFT), aminoimidazolecarboxamide ribonucleotide formyltransferase (AICARFT), thymidylate… CONTINUE READING