Skip to search formSkip to main contentSkip to account menu

Nomifensine

Known as: (R)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine, Nomifensin, 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl- 
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (7)

3',4'-dihydroxynomifensine3'-hydroxy-4'-methoxynomifensine4'-hydroxy-3'-methoxynomifensine4'-hydroxynomifensine

Broader (4)

Antidepressive AgentsDopamine Uptake InhibitorsDopaminergic AgentsIsoquinolines
In BloodNomifensine MaleateNomifensine:MCnc:Pt:Ser/Plas:Qnagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Accumbens dopamine mechanisms in sucrose intake
Review
1999
Review
1999
Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies
Highly Cited
1995
Highly Cited
1995
Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport
Whether amphetamine acts principally at the plasma membrane or at synaptic vesicles is controversial. We find that d-amphetamine… 
Highly Cited
1992
Highly Cited
1992
Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum
Highly Cited
1988
Highly Cited
1988
In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs; implications for the origin of extracellular DOPAC.
Highly Cited
1987
Highly Cited
1987
In vivo evaluation of striatal dopamine reuptake sites using 11C‐nomifensine and positron emission tomography
Abstract In vitro nomifensine demonstrates high affinity and specificity for dopamine reuptake sites in the brain. In the present… 
Highly Cited
1987
Highly Cited
1987
The automated tail suspension test: A computerized device which differentiates psychotropic drugs
Highly Cited
1985
Highly Cited
1985
Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatum
Highly Cited
1983
Highly Cited
1983
Behavioral sensitization and relative hyperresponsiveness of striatal and limbic dopaminergic neurons after repeated methamphetamine treatment.
Highly Cited
1974
Highly Cited
1974
Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum
Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum Biogenic amines released… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)