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Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents.
TLDR
This review discusses efforts to develop rodent models for the study of neurobiological mechanisms underlying chronic alcohol drinking, alcoholism, and abnormal alcohol-seeking behavior in rodents, and indicates innate differences exist between the high alcohol-consuming and low alcohol- consuming rodents in various CNS limbic structures. Expand
REVIEW: The alcohol‐preferring P rat and animal models of excessive alcohol drinking
TLDR
Findings indicate that the P rat can be effectively used in models assessing alcohol‐preference, a genetic predisposition for alcohol abuse and/or alcoholism, and excessive drinking using protocols of binge‐like or relapse‐like drinking. Expand
Phenotypic and Genotypic Characterization of the Indiana University Rat Lines Selectively Bred for High and Low Alcohol Preference
TLDR
The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention. Expand
Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies
TLDR
Overall, the ICSA and ICPC studies indicate that there are a number of receptors, neuronal pathways, and discrete CNS sites involved in brain reward mechanisms. Expand
Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats
TLDR
The findings suggest that EtOH is reinforcing within the posterior VTA of Wistar rats, and the VTA is a functionally heterogeneous structure with regard to EtOH reinforcement. Expand
Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens.
TLDR
The data suggest that ethanol can stimulate the release of both DA and 5-HT in the ACC and that the action of ethanol within the ACC may be mediated in part by 5- HT3 receptors. Expand
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons
TLDR
The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process. Expand
Role of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Mediating Reward
TLDR
The present results suggest that concurrent activation of D1- and D2-type receptors in the shell of the ACB had a cooperative effect on DA-mediated reward processes. Expand
GABAA Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats
TLDR
The results suggest that DA neurons projecting from the anterior VTA to the ACB are tonically inhibited by GABA through its actions at the GABAA receptors. Expand
The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.
TLDR
Salsolinol produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors. Expand
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