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Depression: a new animal model sensitive to antidepressant treatments
Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests. Expand
Behavioral despair in mice: a primary screening test for antidepressants.
The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments. Expand
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests. Expand
"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.
Important differences exist between strains in both the amount of immobility observed and the effects of imipramine, and strain differences should be taken into account in attempts to replicate results from one laboratory to another. Expand
Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor
It is shown that reboxetine has a superior pharmacological selectivity to existing tricyclic antidepressants and selective serotonin reuptake inhibitors when tested in a large number of in vitro and in vivo systems. Expand
Pharmacological Properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological Characterization and Broad Preclinical Efficacy in Cognition and
Acute pharmacological blockade of central histamine H3 receptors (H3Rs) enhances arousal/attention in rodents. However, there is little information available for other behavioral domains or forExpand
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant = 37 picomolar)Expand
Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.
Findings indicate that MPEP exhibits anxiolytic-like effects and low risks for sedation and psychotomimetic side-effects in rodents. Expand
Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity.
It was concluded that immobility depended primarily on the activity of central catecholamines but that caution was required before ascribingimmobility exclusively to activity within a single system. Expand
The automated tail suspension test: A computerized device which differentiates psychotropic drugs
A computerized version of this test (ITEMATIC-TST) which in addition to recording immobility measures the power of the movements, suggesting that the automated test system is not only sensitive to antidepressants but could also be useful for generating activity profiles for different kinds of psychotropic agent. Expand