A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.Expand
The results suggest that the anxiogenic drugs selected activate a restricted set of forebrain areas that are consistent with the theory of an integrated forebrain and hindbrain neuronal system that is important for anxiety states evoked by both drug and environmental manipulations.Expand
Electrophysiological and pathway tracing methods show that stimulation of the ventral medial prefrontal cortex causes a marked post-stimulus inhibition in the vast majority of midbrain raphe 5-hydroxytryptamine neurons tested, and it seems likely that the projection from ventral lateral prefrontal cortex to the mid brain raphe nuclei mediates the responses of 5-Hydroxytiptamine neurons to cortical stimulation.Expand
It is indicated that administration of a tyrosine-free amino acid mixture to rats depletes brain tyrosines to cause a decrease in regional brain catecholamine synthesis and release, and dopaminergic neurones appear to be more vulnerable to tyosine depletion than noradrenergic neurone depletion.Expand
The data show that a transient and limited glutamatergic intervention during development can have chronic behavioural, structural and molecular effects, and are consistent with hypotheses advocating a role for NMDA receptor hypofunction, and aberrant apoptosis, in the neurodevelopmental pathogenesis of the disorder.Expand
Pretreatment with the selective 5‐HT1A receptor antagonist, WAY 100635, blocked the inhibitory effect of paroxetine on5‐HT neuronal activity in the DRN and, at the same time, markedly enhanced the effect ofParoxetines on extracellular 5‐ HT in the FCx.Expand
In vivo juxtacellular labelling methods in urethane-anaesthetised rats were used to establish the neurochemical and morphological identity of a fast-firing population of DRN neurones, which recent data suggest may be GABAergic, and establishes for the first time that fast- firing DRn neurones are GABAergic.Expand
It is concluded that COMT activity specifically affects ED set shifting and is a significant modulator of mPFC DA but not NE under conditions of increased catecholaminergic transmission, suggesting that the links between COMTActivity and PFC function can be modeled in rats and may be specifically mediated by DA.Expand
Both transection of the frontal cortex as well as ablation of the medial region of the prefrontal cortex significantly attenuated the inhibition of 5‐ HT neurones induced by systemic administration of the 5‐HT1A receptor agonist, 8‐OH‐DPAT (0.5–16 μg kg−1, i.v.) in all neurones tested.Expand
A dissociation was found between the neurotransmitter systems involved in different types of cost-benefit decision making, while dopaminergic systems were required for decisions about both effort and delay, and serotonergic Systems were only needed for the latter.Expand