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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
TLDR
The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.
TLDR
Relatively stable PIB retention after 2 years of follow-up in patients with mild Alzheimer's disease suggests that amyloid deposition in the brain reaches a plateau by the early clinical stages of Alzheimer’s disease and therefore may precede a decline in rCMRGlc and cognition.
Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy.
TLDR
Improvement in symptoms with citalopram and cognitive-behavioral therapy was accompanied by a decreased rCBF-response to public speaking bilaterally in the amygdala, hippocampus, and the periamygdaloid, rhinal, and parahippocampal cortices, confirmed by between-group comparisons.
Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study.
TLDR
The functional neuroanatomy of social phobia involves the activation of a phylogenetically older danger-recognition system as indicated by an rCBF pattern of relatively increased cortical rather than subcortical perfusion, indicating that cortical evaluative processes were taxed by public performance.
Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography
TLDR
Regional cerebral blood flow was measured with positron emission tomography in six healthy volunteers at rest and during experimentally induced, sustained cutaneous pain on the dorsum of the right hand or on the anterior cingulate gyrus and the ipsilateral prefrontal cortex to show consistent with an involvement of SI in the spatial discrimination of acute cutaneousPain.
Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
TLDR
Differences in plasma protein binding and metabolism did not explain the species-related differences in brain uptake of three radiolabeled P-glycoprotein substrates across species using positron emission tomography, which is important for interpretation of brain drug delivery when extrapolating preclinical data to humans.
The use of PET in Alzheimer disease
TLDR
Amyloid imaging could be useful as early diagnostic marker of AD and for selecting patients for anti-amyloid-β therapy, while cerebral glucose metabolism could be a suitable PET marker for monitoring disease progression.
Functional neuroanatomical correlates of electrodermal activity: a positron emission tomographic study.
TLDR
It is concluded that the cingulum and the motor cortex, in addition to the parietal and possibly the insular cortex, form part of one or several distributed neural network(s) involved in electrodermal control.
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