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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
This report describes the first human study of a novel amyloid‐imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound‐B (PIB), in 16 patients with diagnosed mild AD and 9Expand
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Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.
Beta amyloid is one of the major histopathological hallmarks of Alzheimer's disease. We recently reported in vivo imaging of amyloid in 16 Alzheimer patients, using the PET ligandExpand
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Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy.
BACKGROUND Neurofunctional changes underlying effective antianxiety treatments are incompletely characterized. This study explored the effects of citalopram and cognitive-behavioral therapy onExpand
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Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study.
OBJECTIVE The central nervous system representation of social phobia (social anxiety disorder) is largely unknown. The aim of this study was to examine brain activity during symptom provocation inExpand
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Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
Species differences occur in the brain concentrations of drugs, but the reasons for these differences are not yet apparent. This study was designed to compare brain uptake of three radiolabeledExpand
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Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography
Abstract Regional cerebral blood flow was measured with positron emission tomography (PET) in six healthy volunteers at rest and during experimentally induced, sustained cutaneous pain on the dorsumExpand
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Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing astrocytes inExpand
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Functional neuroanatomical correlates of electrodermal activity: a positron emission tomographic study.
To reveal areas in the central nervous system of importance for electrodermal control, regional cerebral blood flow (rCBF) was correlated to nonspecific skin conductance fluctuations (NSF) duringExpand
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Manganese induced brain lesions inMacaca fascicularis as revealed by positron emission tomography and magnetic resonance imaging
A series of positron emission tomography scans was made on two monkeys during a 16-month period when they received manganese(IV)oxide by subcutaneous injection. The distribution of [11C]-nomifensineExpand
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