NOD1 gene

Known as: CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 4, NLRC1, CARD4 
This gene plays a role in both apoptosis and immunity.
National Institutes of Health

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ApoptosisCaspase ActivationCaspase-Dependent ApoptosisNOD1 protein, human
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for… (More)
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Highly Cited
2010
Highly Cited
2010
Recognition of Peptidoglycan from the Microbiota by Nod1 Enhances Systemic Innate Immunity
Humans are colonized by a large and diverse bacterial flora (the microbiota) essential for the development of the gut immune… (More)
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Highly Cited
2008
Highly Cited
2008
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Intestinal homeostasis is critical for efficient energy extraction from food and protection from pathogens. Its disruption can… (More)
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Review
2006
Review
2006
Signalling pathways and molecular interactions of NOD1 and NOD2
The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of… (More)
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Highly Cited
2004
Highly Cited
2004
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome… (More)
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Highly Cited
2003
Highly Cited
2003
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
Nucleotide-binding oligomerization domain protein 1 (NOD1) belongs to a family that includes multiple members with NOD and… (More)
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Highly Cited
2003
Highly Cited
2003
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.
Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular… (More)
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Highly Cited
2003
Highly Cited
2003
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.
Nod1 and Nod2 are mammalian proteins implicated in the intracellular detection of pathogen-associated molecular patterns… (More)
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Highly Cited
2001
Highly Cited
2001
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase recruitment domain (CARD) linked to a… (More)
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Highly Cited
2001
Highly Cited
2001
Human Nod1 confers responsiveness to bacterial lipopolysaccharides.
The immune response to microbial pathogens is initiated by recognition of specific pathogen components by host cells both at the… (More)
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