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Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
CD4+CD25+ T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4+CD25− T cells by cell–cell contact and not secretion of suppressor cytokines. In
The immunological and genetic basis of inflammatory bowel disease
TLDR
The most important finding is the identification of mutations in the gene that encodes NOD2 (nucleotide-binding oligomerization domain 2) protein in a subgroup of patients with Crohn's disease.
The immunology of mucosal models of inflammation.
TLDR
This work analyzes the immunology of the IBDs through the lens of the murine models, first by drawing attention to their common features and then by considering individual models at a level of detail necessary to reveal their individual capacities to provide insight into IBD pathogenesis.
Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β
TLDR
Results indicate that CD4+CD25+Foxp3+ regulatory T cells can function as inducers of Th 17 cells and can differentiate into Th17 cells, which have important implications to the understanding of regulatory T cell function and their possible therapeutic use.
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells
TLDR
These studies provide strong evidence that the immunopathologic process characteristic of the two major forms of IBD is associated with very different cytokine secretion patterns, which may determine the type of inflammatory process present.
The fundamental basis of inflammatory bowel disease.
TLDR
It is concluded that IBD is indeed characterized by an abnormal mucosal immune response but that microbial factors and epithelial cell abnormalities can facilitate this response.
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases.
TLDR
This review will explore the cytokine landscape with the view of providing an understanding of how recent and future anticytokine therapies actually function.
Trypan Blue Exclusion Test of Cell Viability
  • W. Strober
  • Biology, Medicine
    Current protocols in immunology
  • 1 May 2001
The protocol described in this appendix allows for light microscopic quantitation of cell viability. Cells are suspended in PBS containing trypan blue and then examined to determine the percentage of
Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells
TLDR
The data support a model in which the differential association of Runx1 with Foxp3 and with RORγt regulates TH-17 differentiation, and suggest that optimal transcription of the gene encoding interleukin 17 required a 2-kilobase promoter and at least one conserved noncoding sequence, CNS-5.
Antibodies to interleukin 12 abrogate established experimental colitis in mice
TLDR
The data demonstrate the pivotal role of IL-12 and IFN-gamma in a TNBS-induced murine model of chronic intestinal inflammation and suggest the potential utility of anti-IL-12 antibodies in patients with Crohn's disease.
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