NHEJ1 wt Allele

Known as: XLF, FLJ12610, Cernunnos Gene 
Human NHEJ1 wild-type allele is located in the vicinity of 2q35 and is approximately 85 kb in length. This allele, which encodes nonhomologous end… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2018
05101519832018

Papers overview

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Highly Cited
2015
Highly Cited
2015
XRCC4 and XLF are two structurally related proteins that function in DNA double-strand break (DSB) repair. Here, we identify… (More)
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2015
2015
Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types… (More)
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2011
2011
The XRCC4-like factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for DNA double… (More)
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2010
2010
DNA ligase IV (LigIV) is critical for nonhomologous end joining (NHEJ), the major DNA double-strand break (DSB) repair pathway in… (More)
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2009
2009
XLF-Cernunnos (XLF) is a component of the DNA ligase IV-XRCC4 (LX) complex, which functions during DNA non-homologous end joining… (More)
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Highly Cited
2008
Highly Cited
2008
Mutations in XLF/Cernunnos (XLF) cause lymphocytopenia in humans, and various studies suggest an XLF role in classical… (More)
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Highly Cited
2008
Highly Cited
2008
XRCC4-like factor (XLF)--also known as Cernunnos--has recently been shown to be involved in non-homologous end-joining (NHEJ… (More)
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2007
2007
DNA double-strand breaks represent one of the most severe forms of DNA damage in mammalian cells. One pathway for repairing these… (More)
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2007
2007
The double-strand DNA break repair pathway, non-homologous DNA end joining (NHEJ), is distinctive for the flexibility of its… (More)
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Highly Cited
2006
Highly Cited
2006
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects… (More)
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