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NHEJ1 gene

Known as: NEJ1, S. CEREVISIAE, HOMOLOG OF, XRCC4-LIKE FACTOR, FLJ12610 
This gene is involved in DNA repair and V(D)J recombination.
National Institutes of Health

Related topics

Related topics

8 relations
DNA RepairDouble Strand Break RepairNHEJ1 protein, humanNon-Homologous DNA End-Joining

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NHEJ1 wt Allele

Papers overview

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2019
2019
The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells
Clastogen exposure can result in chromosomal rearrangements, including large deletions and inversions that are associated with… 
2018
2018
Robust DNA repair in PAXX‐deficient mammalian cells
To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA… 
2014
2014
A role for XLF in DNA repair and recombination in human somatic cells.
2009
2009
Unrelated hematopoietic stem cell transplantation for Cernunnos‐XLF deficiency
Abstract:  Cernunnos‐XLF deficiency is a rare CI characterized by a defective DNA DSB repair mechanism. Its clinical… 
2009
2009
Impaired Replication Stress Response in Cells from Immunodeficiency Patients Carrying Cernunnos/XLF Mutations
Non-Homologous End Joining (NHEJ) is one of the two major pathways of DNA Double Strand Breaks (DSBs) repair. Mutations in human… 
2008
2008
The C-Terminal Domain of Cernunnos/XLF Is Dispensable for DNA Repair In Vivo
ABSTRACT The core nonhomologous end-joining DNA repair pathway is composed of seven factors: Ku70, Ku80, DNA-PKcs, Artemis, XRCC4… 
Review
2008
Review
2008
Role and regulation of human XRCC4‐like factor/cernunnos
In mammalian cells, non‐homologous end joining (NHEJ) is the major double strand break (DSB) repair mechanism during the G1 phase… 
Highly Cited
2007
Highly Cited
2007
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4.
Highly Cited
2007
Highly Cited
2007
Low levels of DNA ligases III and IV sufficient for effective NHEJ
Cells of higher eukaryotes rejoin double strand breaks (DSBs) in their DNA predominantly by a non‐homologous DNA end joining… 
2007
2007
Truncation of NHEJ1 in a patient with polymicrogyria
Polymicrogyria (PMG) is a common malformation of the human cerebral cortex for which both acquired and genetic causes are known… 
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