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NHEJ1 protein, human
Known as:
XLF protein, human
, XRCC4-Like Factor
, FLJ12610 protein, human
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Non-homologous end-joining factor 1 (299 aa, ~33 kDa) is encoded by the human NHEJ1 gene. This protein is involved in both the repair of double…
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National Institutes of Health
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Related topics
Related topics
10 relations
DNA Repair
DNA Repair Gene
DNA repair protein
NHEJ1 gene
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Broader (2)
DNA Repair Enzymes
DNA-Binding Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
XLF and H2AX function in series to promote replication fork stability
Bo-Ruei Chen
,
A. Quinet
,
+9 authors
B. Sleckman
Journal of Cell Biology
2019
Corpus ID: 163167437
Chen et al. show that XLF functions to limit fork reversal during DNA replication. H2AX prevents MRE11-dependent replication…
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Highly Cited
2018
Highly Cited
2018
Outcome of hematopoietic cell transplantation for DNA double‐strand break repair disorders
J. Slack
,
M. Albert
,
+49 authors
Marrow Transplantation
Journal of Allergy and Clinical Immunology
2018
Corpus ID: 3717861
Highly Cited
2013
Highly Cited
2013
A noncatalytic function of the ligation complex during nonhomologous end joining
Jessica Cottarel
,
P. Frit
,
+7 authors
P. Calsou
Journal of Cell Biology
2013
Corpus ID: 473174
Ligase IV, but not its catalytic function, is required for DNA-PK–dependent end synapsis during nonhomologous end joining.
2012
2012
Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV
T. Ochi
,
Qian Wu
,
D. Chirgadze
,
J. Grossmann
,
V. Bolanos-Garcia
,
T. Blundell
Structure
2012
Corpus ID: 16940977
2011
2011
Cernunnos deficiency: a case report.
T. Turul
,
I. Tezcan
,
O. Sanal
Journal of investigational allergology & clinical…
2011
Corpus ID: 25065355
B cell-negative severe combined immunodeficiency (SCID) is caused by molecules involved in the variable (diversity) joining (V[D…
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2010
2010
XLF-III-43, a novel coumarin-aspirin compound, prevents diabetic nephropathy in rats via inhibiting advanced glycation end products.
Hongyan Li
,
Xuguang Zheng
,
Hongbo Wang
,
Yi Zhang
,
Hongqi Xin
,
Xiaoguang Chen
European Journal of Pharmacology
2010
Corpus ID: 6057869
Highly Cited
2008
Highly Cited
2008
XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation
E. Riballo
,
L. Woodbine
,
T. Stiff
,
Sarah A. Walker
,
A. A. Goodarzi
,
P. Jeggo
Nucleic Acids Research
2008
Corpus ID: 9679400
XLF-Cernunnos (XLF) is a component of the DNA ligase IV–XRCC4 (LX) complex, which functions during DNA non-homologous end joining…
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Review
2006
Review
2006
Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system
P. Revy
,
Laurent Malivert
,
J. Villartay
Current Opinion in Allergy and Clinical…
2006
Corpus ID: 19673801
Purpose of review The analysis of immune deficiency conditions in humans has recently allowed the identification of a novel…
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Review
2006
Review
2006
Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
Adam Pavlicek
,
J. Jurka
Biology Direct
2006
Corpus ID: 264864023
BackgroundCernunnos-XLF is a nonhomologous end-joining factor that is mutated in patients with a rare immunodeficiency with…
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1995
1995
DNA recombination is sufficient for retroviral transduction.
J. R. Schwartz
,
S. Duesberg
,
P. Duesberg
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 10908003
Oncogenic retroviruses carry coding sequences that are transduced from cellular protooncogenes. Natural transduction involves two…
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