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Postnatal Growth Failure, Short Life Span, and Early Onset of Cellular Senescence and Subsequent Immortalization in Mice Lacking the Xeroderma Pigmentosum Group G Gene
In vitro studies showed that primary embryonic fibroblasts isolated from the xpg-deficient mice underwent premature senescence and exhibited the early onset of immortalization and accumulation of p53.
Dimerization, translocation and localization of Ku70 and Ku80 proteins.
- M. Koike
- BiologyJournal of radiation research
- 1 September 2002
The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo.
Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal
It is demonstrated that the localization of Ku80 does not completely coincide with that of Ku70, and the idea that Ku80 can translocate to the nucleus using its own NLS independent of the translocated Ku70 is supported.
Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.
Accumulation of Ku80 proteins at DNA double-strand breaks in living cells.
Runx3 interacts with DNA repair protein Ku70.
Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites
It is shown that p300/CBP acetylate RAD52, a human homologous recombination (HR) DNA repair protein, at DSB sites, and inhibition of ataxia telangiectasia mutated (ATM) protein by siRNA or inhibitor treatment demonstrated that the acetylation of RAD52 at D SB sites is dependent on the ATM protein kinase activity.
The C-terminal region of Rad52 is essential for Rad52 nuclear and nucleolar localization, and accumulation at DNA damage sites immediately after irradiation.
Dynamic changes in subcellular localization of cattle XLF during cell cycle, and focus formation of cattle XLF at DNA damage sites immediately after irradiation
It is shown that the localization of cattle XLF changes dynamically during the cell cycle, and these findings might be useful to develop the molecular-targeting therapeutic drug taking XLF as a target molecule for human and domestic animals.