Mitotic Spindle Apparatus
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Abnormal chromosome content — also known as aneuploidy — is the most common characteristic of human solid tumours. It has… Expand The centrosome is the major microtubule-organizing centre of animal cells and through its influence on the cytoskeleton is… Expand The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle… Expand The E2F transcription factor family is known to play a key role in the timely expression of genes required for cell cycle… Expand Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human… Expand Chromosomes are segregated by two antiparallel arrays of microtubules arranged to form the spindle apparatus. During cell… Expand Small molecules that perturb specific protein functions are valuable tools for dissecting complex processes in mammalian cells. A… Expand Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes… Expand We have isolated a human homolog of Xenopus Eg5, a kinesin-related motor protein implicated in the assembly and dynamics of the… Expand p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been… Expand