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Kinetochores
Known as:
Kinetochore
Large multiprotein complexes that bind the centromeres of the chromosomes to the microtubules of the mitotic spindle during metaphase in the cell…
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National Institutes of Health
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Related topics
Related topics
14 relations
Centromere
Microbiological
Mitotic Spindle Apparatus
Process of secretion
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Narrower (6)
Ctf3 protein, S cerevisiae
Kinetochore of condensed chromosome
MCM22 protein, S cerevisiae
NMS complex
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Broader (1)
chromosome, centromeric region
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Emily A. Foley
,
T. Kapoor
Nature reviews. Molecular cell biology
2012
Corpus ID: 9666328
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is…
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Review
2009
Review
2009
The life and miracles of kinetochores
S. Santaguida
,
A. Musacchio
EMBO Journal
2009
Corpus ID: 10930621
Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be…
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Highly Cited
2009
Highly Cited
2009
Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates
Dan Liu
,
G. Vader
,
Martijn J. M. Vromans
,
M. Lampson
,
S. Lens
Science
2009
Corpus ID: 19937218
Successful cell division requires that chromosomes attach to opposite poles of the mitotic spindle (bi-orientation). Aurora B…
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Review
2008
Review
2008
Molecular architecture of the kinetochore–microtubule interface
I. Cheeseman
,
A. Desai
Nature reviews. Molecular cell biology
2008
Corpus ID: 34121605
Segregation of the replicated genome during cell division in eukaryotes requires the kinetochore to link centromeric DNA to…
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Highly Cited
2004
Highly Cited
2004
The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
T. Kitajima
,
Shigehiro A. Kawashima
,
Yoshinori Watanabe
Nature
2004
Corpus ID: 4400426
Meiosis comprises a pair of specialized nuclear divisions that produce haploid germ cells. To accomplish this, sister chromatids…
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Highly Cited
2003
Highly Cited
2003
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
Claire Ditchfield
,
V. L. Johnson
,
+6 authors
Stephen S. Taylor
Journal of Cell Biology
2003
Corpus ID: 1470612
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel…
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Highly Cited
2003
Highly Cited
2003
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
Silke Hauf
,
R. Cole
,
+7 authors
J. Peters
Journal of Cell Biology
2003
Corpus ID: 16278410
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle…
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Highly Cited
2001
Highly Cited
2001
Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells
D. Cimini
,
D. Cimini
,
+4 authors
E. Salmon
Journal of Cell Biology
2001
Corpus ID: 3096551
In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near the spindle equator after anaphase…
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Highly Cited
1998
Highly Cited
1998
Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension
J. Waters
,
Rey-Huei Chen
,
A. Murray
,
E. Salmon
Journal of Cell Biology
1998
Corpus ID: 8071285
A single unattached kinetochore can delay anaphase onset in mitotic tissue culture cells (Rieder, C.L., A. Schultz, R. Cole, G…
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Highly Cited
1995
Highly Cited
1995
The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
C. Rieder
,
R. Cole
,
A. Khodjakov
,
G. Sluder
Journal of Cell Biology
1995
Corpus ID: 6978937
During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome…
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