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Chromosome Conundrum The three-dimensional organization of chromosomal DNA within the cell nucleus plays an important role in… Expand The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell death that occurs during mitosis… Expand Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization of these DNA copy-number changes is… Expand Gene dosage variations occur in many diseases. In cancer, deletions and copy number increases contribute to alterations in the… Expand Cohesion between sister chromatids opposes the splitting force exerted by microtubules, and loss of this cohesion is responsible… Expand In Saccharomyces cerevisiae, MAD2 is required for mitotic arrest if the spindle assembly is perturbed. The human homolog of MAD2… Expand We have developed epifluorescence filter sets and computer software for the detection and discrimination of 27 different DNA… Expand Taxol inhibited HeLa cell proliferation by inducing a sustained mitotic block at the metaphase/anaphase boundary. Half-maximal… Expand Chromosomes can be specifically stained in metaphase spreads and interphase nuclei by in situ hybridization with entire… Expand This report describes the use of fluorescence in situ hybridization for chromosome classification and detection of chromosome… Expand