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Homologous Recombination

Known as: Homologous Recombinations, Recombination, Homologous, Recombinations, Homologous 
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Abstract Genomic instability is a hallmark of cancer, and often is the result of altered DNA repair capacities in tumour cells… Expand
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Review
2019
Review
2019
The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining genomic stability. However, if deployed in… Expand
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Review
2019
Review
2019
BACKGROUND Poly ADP-ribose polymerase (PARP) inhibitors, such as olaparib, are being explored as a treatment option for… Expand
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Review
2019
Review
2019
More than half of cancer patients receive radiotherapy as a part of their cancer treatment. DNA double-strand breaks (DSBs) are… Expand
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Review
2018
Review
2018
BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of… Expand
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Highly Cited
2007
Highly Cited
2007
We describe a new cloning method, sequence and ligation–independent cloning (SLIC), which allows the assembly of multiple DNA… Expand
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Highly Cited
2006
Highly Cited
2006
Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in BLM, which encodes a RecQ helicase, give rise to Bloom's syndrome, a disorder associated with cancer predisposition… Expand
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Highly Cited
1992
Highly Cited
1992
apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these… Expand
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Highly Cited
1985
Highly Cited
1985
A ‘rescuable’ plasmid containing globin gene sequences allowing recombination with homologous chromosomal sequences has enabled… Expand
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