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Homologous Recombination

Known as: Homologous Recombinations, Recombination, Homologous, Recombinations, Homologous 
The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the… 
National Institutes of Health

Related topics

Related topics

24 relations
BRCA2 geneBRCA2 protein, humanBRCA2 wt AlleleDNA Repair Protein RAD51 Homolog 2

Broader (1)

Gene Targeting

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer
Purpose: To assess the prevalence of defective homologous recombination (HR)-based DNA repair in sporadic primary breast cancers… 
Highly Cited
2006
Highly Cited
2006
Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Parp‐1 and Parp‐2 are activated by DNA breaks and have been implicated in the repair of DNA single‐strand breaks (SSB). Their… 
Highly Cited
2003
Highly Cited
2003
Srs2 and Sgs1–Top3 Suppress Crossovers during Double-Strand Break Repair in Yeast
Review
2002
Review
2002
Homologous repair of DNA damage and tumorigenesis:the BRCA connection
Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such… 
Highly Cited
1999
Highly Cited
1999
Sister Chromatid Exchanges Are Mediated by Homologous Recombination in Vertebrate Cells
ABSTRACT Sister chromatid exchange (SCE) frequency is a commonly used index of chromosomal stability in response to environmental… 
Highly Cited
1998
Highly Cited
1998
Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation
ABSTRACT The RAD52 epistasis group is required for recombinational repair of double-strand breaks (DSBs) and shows strong… 
Highly Cited
1998
Highly Cited
1998
Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
Highly Cited
1997
Highly Cited
1997
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
Rat fibroblast cell lines with targeted disruptions of both c-myc gene copies were constructed. Although c-myc null cells are… 
Highly Cited
1994
Highly Cited
1994
Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells.
Double-strand breaks introduced into DNA in vivo have been shown to enhance homologous recombination in a variety of chromosomal… 
Review
1994
Review
1994
Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii.
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